Melanocytes are more responsive to IFN-gamma and produce higher amounts of kynurenine than melanoma cells

Autor(es)

Clara, Renan Orsati ^[1] ; Assmann, Nadine ^[2] ; Ramos Moreno, Ana Carolina ^[1] ; Coimbra, Janine Baptista ^[1] ; Nurenberger, Nadine ^[2] ; Dettmer-Wilde, Katja ^[2] ; Oefner, Peter Josef ^[2] ; Campa, Ana ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Clin Chem, Fac Pharmaceut Sci, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Regensburg, Inst Funct Genom, D-93051 Regensburg - Germany

• Tipo de documento: Artigo Científico
• Fonte: Biological Chemistry; v. 397, n. 1, p. 85-90, JAN 2016.
• Citações Web of Science: 1

Resumo

A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-gamma plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to IFN-gamma. In general, IFN-gamma affected KP in skin cells more than in melanoma cells, supporting IFN-gamma roles in skin physiology and that of stromal cells in modulating the tumor microenvironment. (AU)

• Processo FAPESP: 10/18477-0 - Metabolismo de triptofano em melanomas: O que dizem as células do microambiente?
• Beneficiário: Renan Orsati Clara
• Modalidade de apoio: Bolsas no Brasil - Doutorado