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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Melanocytes are more responsive to IFN-gamma and produce higher amounts of kynurenine than melanoma cells

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Author(s):
Clara, Renan Orsati [1] ; Assmann, Nadine [2] ; Ramos Moreno, Ana Carolina [1] ; Coimbra, Janine Baptista [1] ; Nurenberger, Nadine [2] ; Dettmer-Wilde, Katja [2] ; Oefner, Peter Josef [2] ; Campa, Ana [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Dept Clin Chem, Fac Pharmaceut Sci, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Regensburg, Inst Funct Genom, D-93051 Regensburg - Germany
Total Affiliations: 2
Document type: Journal article
Source: Biological Chemistry; v. 397, n. 1, p. 85-90, JAN 2016.
Web of Science Citations: 1
Abstract

A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-gamma plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to IFN-gamma. In general, IFN-gamma affected KP in skin cells more than in melanoma cells, supporting IFN-gamma roles in skin physiology and that of stromal cells in modulating the tumor microenvironment. (AU)

FAPESP's process: 10/18477-0 - Tryptophan metabolism in melanomas: What do the microenvironment cells tell us?
Grantee:Renan Orsati Clara
Support Opportunities: Scholarships in Brazil - Doctorate