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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effect of aerobic exercise training on regional blood flow and vascular resistance in diabetic rats

Texto completo
Autor(es):
Ferreira Freitas, Sarah Cristina [1] ; Harthmann, Angela d'Avila [2] ; Rodrigues, Bruno [3] ; Irigoyen, Maria-Claudia [2] ; De Angelis, Katia [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Nove Julho, Translat Physiol Lab, BR-01504001 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Med, Hypertens Unit, Heart Inst InCor, Sao Paulo - Brazil
[3] Univ Campinas UNICAMP, Fac Phys Educ FEF, Dept Adapted Phys Educ, Campinas, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: DIABETOLOGY & METABOLIC SYNDROME; v. 7, DEC 21 2015.
Citações Web of Science: 2
Resumo

Background: Hyperglycemia has been associated with decreased blood flow in various organs, leading to tissue damage and dysfunctions. Exercise training (ET) is known to promote beneficial changes in the autonomic nervous system and may have effects on circulation. The aim of this study was to evaluate coronary and renal blood flows and vascular resistances after ET in diabetic rats. Methods: Thirty-two rats were divided into four groups (n = 8): sedentary control (SC), trained control (TC), sedentary diabetic (SD), trained diabetic (TD). Diabetes was induced by an injection of streptozotocin (STZ, 50 mg/kg). The ET was performed on a treadmill for 10 weeks. The blood flows were measured using colored microspheres. Results: The diabetic groups presented hyperglycemia (blood glucose >350 mg/dL) and ET did not change this parameter. The SD group showed reduced renal blood flow when compared to SC group, and ET was able to normalize this parameter in TD rats (SC: 4.3 +/- 0.5; TC: 2.9 +/- 0.3; SD: 1.9 +/- 0.4; TD: 3.2 +/- 0.4 mL/min/g). TD group presented increased coronary blood flow in relation to SD group (SC: 2.3 +/- 0.23; TC: 2.8 +/- 0.5; SD: 1.2 +/- 0.4; TD: 3.0 +/- 0.4 mL/min/g). The heart and kidneys vascular resistance were increased in SD group when compared to SC group, and ET was able to reverse these changes. Conclusions: Given the relevance of cardiomyopathy and nephropathy in mortality of diabetics, our results demonstrated that ET is effective in improving coronary and renal blood flows and vascular resistances in STZ-diabetic rats, reinforcing the positive role of this approach in preventing hyperglycemia-induced long-term organ damage. (AU)

Processo FAPESP: 12/20141-5 - Efeitos do treinamento físico aeróbio, resistido ou combinado em modelos experimentais de disfunções cardiometabólicas associadas à privação dos hormônios ovarianos
Beneficiário:Kátia de Angelis Lobo D Avila
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 07/52419-4 - Papel do estresse oxidativo e do controle autonomico da circulacao na resistencia do miocardio a injuria isquemica no diabete experimental
Beneficiário:Georgia Orsi Candido
Modalidade de apoio: Bolsas no Brasil - Mestrado