Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Ketogenic diet in epileptic children: impact on lipoproteins and oxidative stress

Texto completo
Autor(es):
Lima, Patricia Azevedo [1] ; de Brito Sampaio, Leticia Pereira [2] ; Teixeira Damasceno, Nagila Raquel [3]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Nutr, BR-05508 Sao Paulo - Brazil
[2] Univ Sao Paulo, Neuropediat, Childrens Inst, Hosp Clin, Sch Med, BR-05508 Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Nutr, Sch Publ Hlth, BR-05508 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: NUTRITIONAL NEUROSCIENCE; v. 18, n. 8, p. 337-344, NOV 2015.
Citações Web of Science: 4
Resumo

Objectives: Ketogenic diet (KD) is an important therapy used in the control of drug-refractory seizures. The major goal of this review is to update the knowledge about the adverse effects of KD on lipoproteins, lipid profile, and cardiometabolic risk. Methods: Articles on the effect of the KD on plasma lipoproteins of children and adolescents with refractory epilepsy, which were published in the past 15 years and indexed in the PubMed and MedLine databases, were included. Results: Dyslipidemia was recurrent in children, and adolescents treated with KD. Evidence suggests that hypercholesterolemia promotes structural modifications in low-density lipoprotein particles. Such modifications possibly favor oxidative processes and contribute to changes in the size of lipoproteins, particularly related to small and denser LDL. However, oxidative modifications in LDL of children on KD are not described in the literature. Discussion: The positive effects of KD on the health of children and adolescents with refractory epilepsy are unquestionable. Conversely, this positive role is associated with significant and negative changes in lipid metabolism. Moreover, the positive effects are possibly related to oxidative reactions and unbalance of antioxidants that can contribute to an increased cardiometabolic risk. Therefore, this review invites clinicians and researchers to investigate the lipid and oxidative metabolism in their clinical practice and trials, respectively. (AU)

Processo FAPESP: 14/26094-4 - Dieta cetogênica clássica e modificada: avaliação do potencial terapêutico e impacto sobre o perfil oxidativo, lipidômico, inflamatório e tamanho de lipoproteínas em crianças e adolescentes com epilepsia refratária
Beneficiário:Patricia Azevedo de Lima
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 12/03775-0 - Impacto da dieta cetogênica nas características oxidativas, físicas e lipídicas de lipoproteínas de crianças com epilepsia refratária
Beneficiário:Patricia Azevedo de Lima
Linha de fomento: Bolsas no Brasil - Mestrado