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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ketogenic diet in epileptic children: impact on lipoproteins and oxidative stress

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Author(s):
Lima, Patricia Azevedo [1] ; de Brito Sampaio, Leticia Pereira [2] ; Teixeira Damasceno, Nagila Raquel [3]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Dept Nutr, BR-05508 Sao Paulo - Brazil
[2] Univ Sao Paulo, Neuropediat, Childrens Inst, Hosp Clin, Sch Med, BR-05508 Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Nutr, Sch Publ Hlth, BR-05508 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: NUTRITIONAL NEUROSCIENCE; v. 18, n. 8, p. 337-344, NOV 2015.
Web of Science Citations: 4
Abstract

Objectives: Ketogenic diet (KD) is an important therapy used in the control of drug-refractory seizures. The major goal of this review is to update the knowledge about the adverse effects of KD on lipoproteins, lipid profile, and cardiometabolic risk. Methods: Articles on the effect of the KD on plasma lipoproteins of children and adolescents with refractory epilepsy, which were published in the past 15 years and indexed in the PubMed and MedLine databases, were included. Results: Dyslipidemia was recurrent in children, and adolescents treated with KD. Evidence suggests that hypercholesterolemia promotes structural modifications in low-density lipoprotein particles. Such modifications possibly favor oxidative processes and contribute to changes in the size of lipoproteins, particularly related to small and denser LDL. However, oxidative modifications in LDL of children on KD are not described in the literature. Discussion: The positive effects of KD on the health of children and adolescents with refractory epilepsy are unquestionable. Conversely, this positive role is associated with significant and negative changes in lipid metabolism. Moreover, the positive effects are possibly related to oxidative reactions and unbalance of antioxidants that can contribute to an increased cardiometabolic risk. Therefore, this review invites clinicians and researchers to investigate the lipid and oxidative metabolism in their clinical practice and trials, respectively. (AU)

FAPESP's process: 12/03775-0 - Impact of a ketogenic diet in the oxidative characteristics, physical and lipid lipoproteins of children with intractable epilepsy
Grantee:Patricia Azevedo de Lima
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 14/26094-4 - Diet classic and modified ketogenic: evaluation of the therapeutic potential and impact on the oxidative, lipidomic profile, inflammatory and lipoproteins size in children and adolescents with refractory epilepsy
Grantee:Patricia Azevedo de Lima
Support Opportunities: Scholarships in Brazil - Doctorate