A ruthenium(II) complex with the propionate ion: Synthesis, characterization and cytotoxic activity

Autor(es):Mostrar menos -

Pagoto, Thalita M. P. ^[1] ; Sobrinho, Larissa L. G. ^[1] ; Graminha, Angelica E. ^[2] ; Guedes, Adriana P. M. ^[2] ; Carroccia, Murilo C. ^[3] ; de Oliveira, Pollyanna F. ^[4] ; Silveira-Lacerda, Elisangela P. ^[5] ; Deflon, Victor M. ^[3] ; Tavares, Denise C. ^[4] ; Pivatto, Marcos ^[1] ; Batista, Alzir A. ^[2] ; Von Poelhsitz, Gustavo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Uberlandia, Inst Quim, BR-38400902 Uberlandia, MG - Brazil

^[2] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil

^[4] Univ Franca, BR-14404600 Franca, SP - Brazil

^[5] Univ Fed Goias, Inst Ciencias Biol, BR-74690970 Goiania, Go - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COMPTES RENDUS CHIMIE; v. 18, n. 12, p. 1313-1319, DEC 2015.
• Citações Web of Science: 2

Resumo

The complex {[}Ru(eta(2)-O2CCH2CH3)(dPPe)(2)]PF6 (dppe = 1,2-bis(diphenylphosphino)ethane) was prepared and characterized by elemental analysis, spectroscopic techniques, X-ray crystallography, HRESIMS and HRESIMS/MS. The characterization data are consistent with a cis arrangement for the dppe ligands and a bidentate coordination of the propionate ligand through carboxylate oxygens. Cytotoxicity assays were carried out on human and murine cancer and normal cell lines. In general, the {[}Ru(eta(2)-O2CCH2CH3)(dPPe)(2)]PF6 complex was more cytotoxic than both its precursor cis-{[}RuCl2(dppe)(2)] and the reference metallodrug cisplatin. The best results against the HepG2 human tumour cell line and S180 murine tumour cell line were found with IC50 values of 6.5 +/- 0.2 and 0.18 +/- 0.03 mu M respectively. (C) 2015 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved. (AU)

• Processo FAPESP: 09/54011-8 - EMU: aquisição de difratômetro de raios X de monocristal para análise estrutural de moléculas pequenas e proteínas
• Beneficiário: Victor Marcelo Deflon
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários