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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A ruthenium(II) complex with the propionate ion: Synthesis, characterization and cytotoxic activity

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Author(s):
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Pagoto, Thalita M. P. [1] ; Sobrinho, Larissa L. G. [1] ; Graminha, Angelica E. [2] ; Guedes, Adriana P. M. [2] ; Carroccia, Murilo C. [3] ; de Oliveira, Pollyanna F. [4] ; Silveira-Lacerda, Elisangela P. [5] ; Deflon, Victor M. [3] ; Tavares, Denise C. [4] ; Pivatto, Marcos [1] ; Batista, Alzir A. [2] ; Von Poelhsitz, Gustavo [1]
Total Authors: 12
Affiliation:
[1] Univ Fed Uberlandia, Inst Quim, BR-38400902 Uberlandia, MG - Brazil
[2] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil
[4] Univ Franca, BR-14404600 Franca, SP - Brazil
[5] Univ Fed Goias, Inst Ciencias Biol, BR-74690970 Goiania, Go - Brazil
Total Affiliations: 5
Document type: Journal article
Source: COMPTES RENDUS CHIMIE; v. 18, n. 12, p. 1313-1319, DEC 2015.
Web of Science Citations: 2
Abstract

The complex {[}Ru(eta(2)-O2CCH2CH3)(dPPe)(2)]PF6 (dppe = 1,2-bis(diphenylphosphino)ethane) was prepared and characterized by elemental analysis, spectroscopic techniques, X-ray crystallography, HRESIMS and HRESIMS/MS. The characterization data are consistent with a cis arrangement for the dppe ligands and a bidentate coordination of the propionate ligand through carboxylate oxygens. Cytotoxicity assays were carried out on human and murine cancer and normal cell lines. In general, the {[}Ru(eta(2)-O2CCH2CH3)(dPPe)(2)]PF6 complex was more cytotoxic than both its precursor cis-{[}RuCl2(dppe)(2)] and the reference metallodrug cisplatin. The best results against the HepG2 human tumour cell line and S180 murine tumour cell line were found with IC50 values of 6.5 +/- 0.2 and 0.18 +/- 0.03 mu M respectively. (C) 2015 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved. (AU)

FAPESP's process: 09/54011-8 - Acquisition of a single-crystal X-ray diffractometer for the structural analysis of small molecules and proteins
Grantee:Victor Marcelo Deflon
Support Opportunities: Multi-user Equipment Program