Self-assembled penetratin-deferasirox micelles as potential carriers for hydrophobic drug delivery

Autor(es)

Goswami, Dibakar ^{[1, 2]} ; Vitorino, Hector Aguilar ^[1] ; Teresa Machini, M. ^[3] ; Esposito, Breno P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo - Brazil

^[2] Bhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra - India

^[3] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Biopolymers; v. 104, n. 6, p. 712-719, NOV 2015.
• Citações Web of Science: 5

Resumo

There has been a growing interest in the use of micelles with nanofiber geometry as nanocarriers for hydrophobic drugs. Here we show that the conjugate of penetratin, a cell-penetrating peptide (CPP) with blood-brain barrier (BBB) permeability, and deferasirox (DFX), a hydrophobic iron chelator, self-assembles to form micelles at a very low concentration (approximate to 15mg/L). The critical micelle concentration (CMC) was determined, and the micelles were used for solubilizing curcumin, a hydrophobic anti-neurodegenerative drug, for successful delivery across RBE4 cells, a BBB model. Transmission Electron Microscope images of the curcumin-loaded micelles confirmed the formation of nanofibers. These results indicate the potential of CPP-drug conjugates for use as nanocarriers. (c) 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 712-719, 2015. (AU)

• Processo FAPESP: 11/18958-0 - Conjugados quelante-peptídeo permeáveis à barreira hematoencefálica como protetores contra toxicidade induzida por ferro
• Beneficiário: Dibakar Goswami
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado