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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Self-assembled penetratin-deferasirox micelles as potential carriers for hydrophobic drug delivery

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Author(s):
Goswami, Dibakar [1, 2] ; Vitorino, Hector Aguilar [1] ; Teresa Machini, M. [3] ; Esposito, Breno P. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo - Brazil
[2] Bhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra - India
[3] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Biopolymers; v. 104, n. 6, p. 712-719, NOV 2015.
Web of Science Citations: 5
Abstract

There has been a growing interest in the use of micelles with nanofiber geometry as nanocarriers for hydrophobic drugs. Here we show that the conjugate of penetratin, a cell-penetrating peptide (CPP) with blood-brain barrier (BBB) permeability, and deferasirox (DFX), a hydrophobic iron chelator, self-assembles to form micelles at a very low concentration (approximate to 15mg/L). The critical micelle concentration (CMC) was determined, and the micelles were used for solubilizing curcumin, a hydrophobic anti-neurodegenerative drug, for successful delivery across RBE4 cells, a BBB model. Transmission Electron Microscope images of the curcumin-loaded micelles confirmed the formation of nanofibers. These results indicate the potential of CPP-drug conjugates for use as nanocarriers. (c) 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 712-719, 2015. (AU)

FAPESP's process: 11/18958-0 - Chelator-peptide conjugates permeable to the blood-brain barrier as protectors against iron-induced toxicity
Grantee:Dibakar Goswami
Support Opportunities: Scholarships in Brazil - Post-Doctoral