Development and characterization of metallo organic frameworks based on cyclodextrin

• Grant number: 14/10888-1
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): August 01, 2014
• Effective date (End): May 01, 2016
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Leila Aparecida Chiavacci Favorin
• Grantee: Marina Paiva Abuçafy
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated scholarship(s): 15/01199-0 - Encapsulation and drug release of metalorganic framework based on cyclodextrin, BE.EP.MS

Abstract

The carriers and drug delivery systems represent the pharmaceutical area with more potential application providing greater stability and better therapeutic efficacy. The materials that are most commonly used as carriers of drugs, such as liposomes, nanoparticles, nanoemulsions or micelles have already been explored in the literature and are known limitations, especially the low loading of drug (usually less than 5% by weight of drug transported relative to carrier materials). Aiming to overcome these limitations the development of new materials carriers able to overcome new barriers and exhibit optimized properties is desired. Recently, a new material was developed from porous hybrid solids for this purpose and these materials are known as metal-organic frameworks or Metal-Organic Frameworks (MOFs) (Horcajada, 2010). The metal-organic frameworks belong to a new class of materials from the group of coordination polymers and are highly crystalline porous solids which have two main components: a metal ion and organic molecule ligand. In search of overrunning MOFs developed by 2010, which consisted of non-renewable and toxic materials, the new MOFs are composed of natural compounds, but having mostly as a negative point, the asymmetry of the units that are not amenable crystallization. One of the strategies that can be used to overcome this problem is to use cyclodextrin as an organic binder (SMALDONE et al., 2010) MOFs are synthesized based on the cyclodextrin with alkali metals and transition through the vapor diffusion method at room temperature and under heating. After its synthesis, the MOFs will be activated with heat treatment to release the solvents from the pores. The systems will be characterized by XRD, NMR, TGA, DSC and your pores will be analyzed by the method of nitrogen adsorption. Cytotoxicity test of the material will be also performed. In a last step, the drugs will be incorporated into MOFs through the saturation of the system under heating. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ABUCAFY, MARINA P.; CAETANO, BRUNO L.; CHIARI-ANDREO, BRUNA G.; FONSECA-SANTOS, BRUNO; DO SANTOS, ALINE M.; CHORILLI, MARLUS; CHIAVACCI, LEILA A.. Supramolecular cyclodextrin-based metal-organic frameworks as efficient carrier for anti-inflammatory drugs. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 127, p. 112-119, JUN 2018. (14/10888-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ABUÇAFY, Marina Paiva. Development of metal-organic framework based on cyclodextrin for drug release. 2016. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.