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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Supramolecular cyclodextrin-based metal-organic frameworks as efficient carrier for anti-inflammatory drugs

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Author(s):
Abucafy, Marina P. [1] ; Caetano, Bruno L. [1] ; Chiari-Andreo, Bruna G. [1, 2] ; Fonseca-Santos, Bruno [1] ; do Santos, Aline M. [1] ; Chorilli, Marlus [1] ; Chiavacci, Leila A. [1]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Dept Drugs & Med, Sch Pharmaceut Sci, Araraquara, SP - Brazil
[2] Univ Araraquara UNIARA, Dept Biol & Hlth Sci, Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS; v. 127, p. 112-119, JUN 2018.
Web of Science Citations: 14
Abstract

Drug delivery systems have been used to reduce adverse effects and improve the efficacy of therapies. Drug carriers have been developed over the years, but they have limitations. gamma-cyclodextrin-based metal-organic frameworks (gamma-CD-MOF) have significant advantages due to their biocompatibility and environmental safety, besides crystallinity and porosity. Herein, gamma-CD-MOFs were synthesised with different metals as nodes and investigated. Uniform mesoporous gamma-CD-MOFs were obtained and showed an absence of toxicity in HepG2 and Caco-2 cells. The longer controlled release was verified for gamma-CD-MOFs, with a maximum of 62% released in 12 h. An inflammation experiment was performed in mice and activity equivalent to the positive control was verified. gamma-KCD-MOFs and gamma-NaCD-MOFs reached activity after 6 h of administration, however this happened after 24 h in gamma-FeCD-MOFs, being more effective than the positive control. Considering the ability for drug entrapment, easy preparation and controlled release, this class of material allows potential applications in drug delivery systems. (AU)

FAPESP's process: 14/10888-1 - Development and characterization of metallo organic frameworks based on cyclodextrin
Grantee:Marina Paiva Abuçafy
Support Opportunities: Scholarships in Brazil - Master