Supramolecular cyclodextrin-based metal-organic frameworks as efficient carrier for anti-inflammatory drugs

Author(s)

Abucafy, Marina P. ^[1] ; Caetano, Bruno L. ^[1] ; Chiari-Andreo, Bruna G. ^{[1, 2]} ; Fonseca-Santos, Bruno ^[1] ; do Santos, Aline M. ^[1] ; Chorilli, Marlus ^[1] ; Chiavacci, Leila A. ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Dept Drugs & Med, Sch Pharmaceut Sci, Araraquara, SP - Brazil

^[2] Univ Araraquara UNIARA, Dept Biol & Hlth Sci, Araraquara, SP - Brazil

• Document type: Journal article
• Source: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS; v. 127, p. 112-119, JUN 2018.
• Web of Science Citations: 14

Abstract

Drug delivery systems have been used to reduce adverse effects and improve the efficacy of therapies. Drug carriers have been developed over the years, but they have limitations. gamma-cyclodextrin-based metal-organic frameworks (gamma-CD-MOF) have significant advantages due to their biocompatibility and environmental safety, besides crystallinity and porosity. Herein, gamma-CD-MOFs were synthesised with different metals as nodes and investigated. Uniform mesoporous gamma-CD-MOFs were obtained and showed an absence of toxicity in HepG2 and Caco-2 cells. The longer controlled release was verified for gamma-CD-MOFs, with a maximum of 62% released in 12 h. An inflammation experiment was performed in mice and activity equivalent to the positive control was verified. gamma-KCD-MOFs and gamma-NaCD-MOFs reached activity after 6 h of administration, however this happened after 24 h in gamma-FeCD-MOFs, being more effective than the positive control. Considering the ability for drug entrapment, easy preparation and controlled release, this class of material allows potential applications in drug delivery systems. (AU)

• FAPESP's process: 14/10888-1 - Development and characterization of metallo organic frameworks based on cyclodextrin
• Grantee: Marina Paiva Abuçafy
• Support Opportunities: Scholarships in Brazil - Master