| Full text | |
| Author(s): |
Abucafy, Marina P.
[1]
;
Caetano, Bruno L.
[1]
;
Chiari-Andreo, Bruna G.
[1, 2]
;
Fonseca-Santos, Bruno
[1]
;
do Santos, Aline M.
[1]
;
Chorilli, Marlus
[1]
;
Chiavacci, Leila A.
[1]
Total Authors: 7
|
| Affiliation: | [1] Sao Paulo State Univ UNESP, Dept Drugs & Med, Sch Pharmaceut Sci, Araraquara, SP - Brazil
[2] Univ Araraquara UNIARA, Dept Biol & Hlth Sci, Araraquara, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS; v. 127, p. 112-119, JUN 2018. |
| Web of Science Citations: | 14 |
| Abstract | |
Drug delivery systems have been used to reduce adverse effects and improve the efficacy of therapies. Drug carriers have been developed over the years, but they have limitations. gamma-cyclodextrin-based metal-organic frameworks (gamma-CD-MOF) have significant advantages due to their biocompatibility and environmental safety, besides crystallinity and porosity. Herein, gamma-CD-MOFs were synthesised with different metals as nodes and investigated. Uniform mesoporous gamma-CD-MOFs were obtained and showed an absence of toxicity in HepG2 and Caco-2 cells. The longer controlled release was verified for gamma-CD-MOFs, with a maximum of 62% released in 12 h. An inflammation experiment was performed in mice and activity equivalent to the positive control was verified. gamma-KCD-MOFs and gamma-NaCD-MOFs reached activity after 6 h of administration, however this happened after 24 h in gamma-FeCD-MOFs, being more effective than the positive control. Considering the ability for drug entrapment, easy preparation and controlled release, this class of material allows potential applications in drug delivery systems. (AU) | |
| FAPESP's process: | 14/10888-1 - Development and characterization of Metallo Organic Frameworks based on Cyclodextrin |
| Grantee: | Marina Paiva Abuçafy |
| Support Opportunities: | Scholarships in Brazil - Master |