Development of metal-organic framework based on cyclodextrin for drug release

Author(s)

Marina Paiva Abuçafy

• Document type: Master's Dissertation
• Press: Araraquara. 2016-07-06.
• Institution: Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara
• Defense date: 2016-05-30
• Advisor: Leila Aparecida Chiavacci; Bruno Leonardo Caetano

Abstract

The development of new drug carrier systems has contributed to improving the quality of life with respect to lessen the side effects of drugs and increase patient survival. Aiming to overcome the limitations of carriers already explored in the literature, we seek to develop new carrier materials that have higher drug encapsulation capacity. Among these new materials are the organic metallo networks (MOFs), which are formed by organic ligands and metal centers that combine to form crystalline and highly porous network. Thus, the focus of this work was to synthesize and characterize MOFs cyclodextrin basis, different metals such as potassium (γ-KCD), sodium (γ-NACD) and iron (γ-FECD), and to evaluate the release capacity of these drug materials. The MOFs were synthesized following a method described in the literature with some modifications: the cyclodextrin and the metal salt were solubilized in water and then placed in methanol diffusion after formation of the crystals, they were activated with dichloromethane. The -ray diffraction (XRD) showed the crystallinity and the presence of characteristic peaks of MOFs cyclodextrin base, reported in the literature. The thermal analysis (TG and DSC) confirmed the formation of networks by linking the cyclodextrin and the metal. The micrographs of scanning electron microscopy (SEM) show that different geometries of structures formed as cubical for γ-KCD and γ-NACD and form of sticks for γ-FECD, and that after activation is possible to demonstrate the presence of pores. The model drug, sodium diclofenac, was incorporated in MOFs, which was confirmed by vibrational infrared spectroscopy (IR), and the results show that the material has a high encapsulation efficiency greater than 60%. The obtained release profiles showed a drug release control effect in PBS, suggesting that drug release occurs due to the combination of two or more processes, such as diffusion of the drug and erosion of the metal-organic framework. In this way, we can say that the developed MOFs are biocompatible, have great ability to encapsulate the drug in addition to having controlled release behavior. (AU)

• FAPESP's process: 14/10888-1 - Development and characterization of metallo organic frameworks based on cyclodextrin
• Grantee: Marina Paiva Abuçafy
• Support Opportunities: Scholarships in Brazil - Master