Advanced synthesis of nanocapsules based on biocompatible metal- organic frameworks as advanced drug delivery system

• Grant number: 18/00442-7
• Support type: Scholarships abroad - Research Internship - Doctorate
• Effective date (Start): April 01, 2018
• Effective date (End): November 30, 2018
• Field of knowledge: Health Sciences - Pharmacy
• Principal researcher: Leila Aparecida Chiavacci Favorin
• Grantee: Marina Paiva Abuçafy
• Supervisor abroad: Christian Serre
• Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Research place: École Normale Supérieure, Paris (ENS), France
• Associated to the scholarship: 16/11563-4 - Supramolecular capsules based on metal-organic framework applied for drug release, BP.DR

Abstract

This Project is associated to FAPESP doctorate fellowship process number 2016/11563-4, entitled "Supramolecular capsules derived from metal-organic framework for drug delivery". The research will be realized under supervisor of the Dr. Christian Serre (Institut des Matériaux Poreux de Paris, FRE 2000 CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de Paris (ESPCI) and Ecole Normale Supérieure (ENS)). He was chosen as responsible for this internship due to his strong expertise in the synthesis and characterization of nanoparticles of porous biocompatible hybrid solids such as Metal- organic frameworks (MOFs). Dr. Christian has been leading several projects related to bioapplications of MOF including a prestigious European Research Council Starting grant (2008-2013) devoted to the development of new concepts of bioapplications based on MOFs. He has also strong collaborations with the team of Dr. Cédric Boissière from LCMCP (Paris 6 university), expert in spray drying synthesis of porous solids, and initiated recently collaboration with Dr. Nicolas Bremond from LCMD laboratory (ESPCI), specialist of colloidal physic-chemistry. This will allow access to spray-driers for the synthesis of MOFs as well as assistance for the development of nanocapsules through nanoemulsion techniques. The time required to develop the research activities in the proposal are eight months. The aim of this project is during the internship in the French laboratory to explore the study of development nanocapsules based on biocompatible metal organic frameworks with size and shapes controlled and apply this material as drug delivery system. The first step of experimental work will be synthesis the nanocapsules either by nanoemulsion or through spray- drying. After development, the drug incorporation and drug release will be monitored through UV-Vis, HPLC, TGA and elemental analysis (EDX, ICP), which will also allow quantifying and analyzing kinetic release. (AU)