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Synthesis and characterization of Fe3O4-Albumin nanoparticles for drug delivery

Grant number: 17/25523-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2018
Effective date (End): February 28, 2019
Field of knowledge:Engineering - Materials and Metallurgical Engineering
Principal Investigator:Aroldo Geraldo Magdalena
Grantee:Renata Pfeilsticker Neves
Home Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil


Salicylic acid (SA) is a very used, non-steroidal, compound in the medical field owing to its anti-inflammatory, antibacterial, and antifungal properties.[1][2] Recent studies have indicated that SA is relevant for the treatment and prevention of diseases such as diabetes, cancer, arthritis, fungal infections, etc.[1][2][3] In the last years, nanotechnology has advanced and its application in the clinical setting became object of research. Multifunctional nanoparticles can combine multiple therapeutic functions, imaging capabilities such as magnetic resonance imaging (MRI), remotely controlled and targeted drug delivery and hyperthermia function.[4][5]Fe3O4 has been considered a fitting material for biological magnetic applications due to its low toxicity, favorable biocompatibility and biodegradability, super-paramagnetic properties and high chemical stability.[4][6][7] As follows, iron oxide nanoparticles might be used to carry SA for specific drug delivery with controlled release.The surface of Fe3O4 nanoparticles may be modificated using bovine serum albumin (BSA), creating a core-shell structured nanoparticle. Albumin has a hydrophilic nature which improves the dispersion of iron oxide nanoparticles in water[2][6], it is also biocompatible, biodegradable, non-immunogenic and it is not toxic.[8][9] Studies have shown that albumin can be well tolerated without any serious side-effects and it has a high binding capacity, meaning that a significant amount of SA could be carried.[9] This project is intended to study the synthesis and characterization of the Fe3O4-Albumin system and assess the incorporation and delivery of salicylic acid (SA). This is a current subject and has shown great importance to the biomedical field. The nanoparticles' synthesis will be achieved through the co-precipitation method. The results will be compared with other researches related to functionalized Fe3O4 nanoparticles and other drug delivery nanoparticles. (AU)