Antiproliferative Constituents of Geopropolis from the Bee Melipona scutellaris

Autor(es)

da Cunha, Marcos Guilherme ^{[1, 2]} ; Rosalen, Pedro Luiz ^[1] ; Franchin, Marcelo ^[1] ; de Alencar, Severino Matias ^[3] ; Ikegaki, Masaharu ^[4] ; Ransom, Tanya ^[2] ; Beutler, John Albert ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Piracicaba, SP - Brazil

^[2] NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 - USA

^[3] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Piracicaba, SP - Brazil

^[4] Univ Fed Alfenas, Alfenas, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Planta Medica; v. 82, n. 3, p. 190-194, FEB 2016.
• Citações Web of Science: 14

Resumo

Fractionation of geopropolis from Melipona scutellaris, guided by antiproliferative activity against two colon cancer cell lines (COLO205 and KM12), led to the isolation of two new cinnamic acid esters, mammea-type coumarins 5,7-dihydroxy-6(3-methyl-2-butenyl)-8-(4-cinnamoyl-3-methyl-1-oxobutyl)- 4-propyl-coumarin (1) and 5,7-dihydroxy-6-(4-cinnamoyl-3-methyl-1-oxobutyl)-4-phenylcoumarin (2), along with five known coumarins, mammeigin (3), hydroxymammeigin (4), mammeisin (5), cinnamoyloxy-mammeisin (6), and mammein (7), and the prenylated benzophenone ent-nemorosone (8). Among the isolated compounds, 5 and 7 showed the highest cell growth inhibition against COLO205 (GI(50) 9.7 and 10.7 mu M, respectively) and KM12 (GI(50) 12.0 and 10.9 mu M, respectively). The presence of these compounds suggests that plants of Clusiaceae family, especially the genera Kielmeyera and Clusia, are likely to be major sources of geopropolis produced by M. scutellaris. (AU)

• Processo FAPESP: 12/22002-2 - Identificação química de biocompostos e alvos moleculares da geoprópolis sobre células cancerosas
• Beneficiário: Marcos Guilherme da Cunha
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 11/23635-6 - Avaliação farmacológica e isolamento de moléculas bioativas da fração hexânica da geoprópolis de melipona scutellaris
• Beneficiário: Marcos Guilherme da Cunha
• Modalidade de apoio: Bolsas no Brasil - Doutorado