Antiproliferative Constituents of Geopropolis from the Bee Melipona scutellaris

Author(s)

da Cunha, Marcos Guilherme ^{[1, 2]} ; Rosalen, Pedro Luiz ^[1] ; Franchin, Marcelo ^[1] ; de Alencar, Severino Matias ^[3] ; Ikegaki, Masaharu ^[4] ; Ransom, Tanya ^[2] ; Beutler, John Albert ^[2]

Affiliation

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Piracicaba, SP - Brazil

^[2] NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 - USA

^[3] Univ Sao Paulo, Luiz de Queiroz Coll Agr, Piracicaba, SP - Brazil

^[4] Univ Fed Alfenas, Alfenas, MG - Brazil

• Document type: Journal article
• Source: Planta Medica; v. 82, n. 3, p. 190-194, FEB 2016.
• Web of Science Citations: 14

Abstract

Fractionation of geopropolis from Melipona scutellaris, guided by antiproliferative activity against two colon cancer cell lines (COLO205 and KM12), led to the isolation of two new cinnamic acid esters, mammea-type coumarins 5,7-dihydroxy-6(3-methyl-2-butenyl)-8-(4-cinnamoyl-3-methyl-1-oxobutyl)- 4-propyl-coumarin (1) and 5,7-dihydroxy-6-(4-cinnamoyl-3-methyl-1-oxobutyl)-4-phenylcoumarin (2), along with five known coumarins, mammeigin (3), hydroxymammeigin (4), mammeisin (5), cinnamoyloxy-mammeisin (6), and mammein (7), and the prenylated benzophenone ent-nemorosone (8). Among the isolated compounds, 5 and 7 showed the highest cell growth inhibition against COLO205 (GI(50) 9.7 and 10.7 mu M, respectively) and KM12 (GI(50) 12.0 and 10.9 mu M, respectively). The presence of these compounds suggests that plants of Clusiaceae family, especially the genera Kielmeyera and Clusia, are likely to be major sources of geopropolis produced by M. scutellaris. (AU)

• FAPESP's process: 12/22002-2 - Chemical elucidation of biocompounds and molecular targets of geopropolis on cancer cell lines
• Grantee: Marcos Guilherme da Cunha
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 11/23635-6 - Isolation and pharmacological evaluation of bioactive molecules from hexane fraction of M. scutellaris geopropolis
• Grantee: Marcos Guilherme da Cunha
• Support Opportunities: Scholarships in Brazil - Doctorate