Natural products are historically considered as sources of bioactive compounds against a variety of pathological conditions. Among these products, propolis, a resinous substance collected by bees, stands out for presenting a considerable range of pharmacological activities related. Its chemical composition is variable, depending on the biodiversity of the region where it is collected, and may have different patterns of biological responses. However, most studies have reported the properties inherent in propolis collected by Apis mellifera bees, whereas other types of propolis collected by bees from different species continue to edge of knowledge and lack of information on its chemical constitution and biological properties. The geopropolis is a different type of propolis collected by native stingless bees, for example, Melipona scutellaris. In addition to resins, this product also contains wax and soil in its composition, making it unique and also devoid of economic value added, with few studies on their chemical and biological activities. Recent studies indicate that this has essentially apolar chemical composition, and its chemical hexane fraction has interesting antimicrobial activity against Staphylococcus aureus, anti-inflammatory and analgesic, but its potential, while promising, is still not fully elucidated. The objective of this work is to expand knowledge about the chemical and pharmacological properties of geopropolis, represented by its bioactive hexane fraction, conducting a study to find the compound responsible for activity on S. aureus, and a screening of pharmacological activities of the hexane fraction. Will be assessed the following properties: 1) Citototoxity, 2) bone remodeling, 3) activity of matrix metalloproteinase, 4) Antioxidant and 5) antitumor. The results will be initially submitted to an exploratory analysis to determine the best statistical test, and then applied the test more convenient for each analysis presented in this work. In the end, is expected to expand knowledge about the pharmacological potential of geopropolis, thus, a guide for the isolation and identification (s) principle (s) active (s) responsible (s) by the activity that presents the best result.
News published in Agência FAPESP Newsletter about the scholarship: