Modified Beer-Lambert law for blood flow

Autor(es)

Baker, Wesley B. ^[1] ; Parthasarathy, Ashwin B. ^[1] ; Busch, David R. ^{[1, 2]} ; Mesquita, Rickson C. ^[3] ; Greenberg, Joel H. ^[4] ; Yodh, A. G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 - USA

^[2] Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 - USA

^[3] Univ Estadual Campinas, Inst Phys, BR-13083859 Campinas, SP - Brazil

^[4] Univ Penn, Dept Neurol, Philadelphia, PA 19104 - USA

• Tipo de documento: Artigo Científico
• Fonte: BIOMEDICAL OPTICS EXPRESS; v. 5, n. 11, p. 4053-4075, NOV 1 2014.
• Citações Web of Science: 48

Resumo

We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues. (C) 2014 Optical Society of America (AU)

• Processo FAPESP: 12/02500-8 - Desenvolvimento de instrumentação e metodologias para monitoramento de oxigenação, fluxo sanguíneo e metabolismo cerebral com espectroscopias ópticas de difusão
• Beneficiário: Rickson Coelho Mesquita
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs