| Full text | |
| Author(s): |
Baker, Wesley B.
[1]
;
Parthasarathy, Ashwin B.
[1]
;
Busch, David R.
[1, 2]
;
Mesquita, Rickson C.
[3]
;
Greenberg, Joel H.
[4]
;
Yodh, A. G.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 - USA
[2] Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 - USA
[3] Univ Estadual Campinas, Inst Phys, BR-13083859 Campinas, SP - Brazil
[4] Univ Penn, Dept Neurol, Philadelphia, PA 19104 - USA
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | BIOMEDICAL OPTICS EXPRESS; v. 5, n. 11, p. 4053-4075, NOV 1 2014. |
| Web of Science Citations: | 48 |
| Abstract | |
We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues. (C) 2014 Optical Society of America (AU) | |
| FAPESP's process: | 12/02500-8 - Instrumentation and methodology development for cerebral oxygenation, blood flow and metabolic monitoring with diffuse optical spectroscopies |
| Grantee: | Rickson Coelho Mesquita |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology |
| Grantee: | Fernando Cendes |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |