Phase 1 Clinical Trial on the Effect of Palatal Brushing on Denture Stomatitis

Autor(es)

Kabawat, Marla ^[1] ; de Souza, Raphael F. ^[2] ; Badaro, Mauricio M. ^[2] ; de Koninck, Louis ^[1] ; Barbeau, Jean ^[1] ; Rompre, Pierre ^{[3, 1]} ; Emami, Elham ^[3]

Afiliação do(s) autor(es)

^[1] Univ Montreal, Fac Dent, Dept Dent Restaurat, Montreal, PQ H3C 3J7 - Canada

^[2] Univ Sao Paulo, Ribeirao Preto Dent Sch, Dept Dent Mat & Prosthodont, Ribeirao Preto, SP - Brazil

^[3] Univ Montreal, Fac Dent, Dept Stomatol, Montreal, PQ H3C 3J7 - Canada

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Prosthodontics; v. 27, n. 4, p. 311-319, JUL-AUG 2014.
• Citações Web of Science: 5

Resumo

Purpose: This study aimed to assess the efficacy of palatal brushing in the treatment of denture stomatitis. Materials and Methods: After screening 143 individuals with a potential diagnosis of denture stomatitis, 48 patients (mean age: 66.0 +/- 11.2 years) were enrolled in a two-center phase 1 clinical trial with a one-group pretest/posttest design. The intervention of interest was manual palatal brushing after each meal and before bedtime. Clinical and microbiologic examinations were performed at baseline and 1 and 3 months after treatment. Additional data were obtained using a validated questionnaire. The primary and secondary outcomes were the remission of denture stomatitis and diminution of Candida colony-forming units (CFUs), respectively. Descriptive and nonparametric statistical tests were conducted to analyze the data. Results: At the 3-month follow-up, denture stomatitis was completely cured in 10.4% of the participants, and 70.8% of denture wearers showed improvement in the clinical signs of denture stomatitis. There was a significant reduction in the area and severity of the palatal inflammation (P < .0001). The effect size ranged from medium to large (0.34 to 0.54) depending on the classification used for the diagnosis of denture stomatitis. A significant reduction in the number of Candida CFUs isolated from the palatal mucosa and dentures (P <= .05) was observed. Conclusions: The results of this study suggest that palatal brushing is an effective treatment of denture stomatitis. (AU)

• Processo FAPESP: 12/04234-3 - Efeito da escovação do palato sobre a estomatite relacionada à prótese
• Beneficiário: Raphael Freitas de Souza
• Modalidade de apoio: Auxílio à Pesquisa - Regular