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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Phase 1 Clinical Trial on the Effect of Palatal Brushing on Denture Stomatitis

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Author(s):
Kabawat, Marla [1] ; de Souza, Raphael F. [2] ; Badaro, Mauricio M. [2] ; de Koninck, Louis [1] ; Barbeau, Jean [1] ; Rompre, Pierre [3, 1] ; Emami, Elham [3]
Total Authors: 7
Affiliation:
[1] Univ Montreal, Fac Dent, Dept Dent Restaurat, Montreal, PQ H3C 3J7 - Canada
[2] Univ Sao Paulo, Ribeirao Preto Dent Sch, Dept Dent Mat & Prosthodont, Ribeirao Preto, SP - Brazil
[3] Univ Montreal, Fac Dent, Dept Stomatol, Montreal, PQ H3C 3J7 - Canada
Total Affiliations: 3
Document type: Journal article
Source: International Journal of Prosthodontics; v. 27, n. 4, p. 311-319, JUL-AUG 2014.
Web of Science Citations: 5
Abstract

Purpose: This study aimed to assess the efficacy of palatal brushing in the treatment of denture stomatitis. Materials and Methods: After screening 143 individuals with a potential diagnosis of denture stomatitis, 48 patients (mean age: 66.0 +/- 11.2 years) were enrolled in a two-center phase 1 clinical trial with a one-group pretest/posttest design. The intervention of interest was manual palatal brushing after each meal and before bedtime. Clinical and microbiologic examinations were performed at baseline and 1 and 3 months after treatment. Additional data were obtained using a validated questionnaire. The primary and secondary outcomes were the remission of denture stomatitis and diminution of Candida colony-forming units (CFUs), respectively. Descriptive and nonparametric statistical tests were conducted to analyze the data. Results: At the 3-month follow-up, denture stomatitis was completely cured in 10.4% of the participants, and 70.8% of denture wearers showed improvement in the clinical signs of denture stomatitis. There was a significant reduction in the area and severity of the palatal inflammation (P < .0001). The effect size ranged from medium to large (0.34 to 0.54) depending on the classification used for the diagnosis of denture stomatitis. A significant reduction in the number of Candida CFUs isolated from the palatal mucosa and dentures (P <= .05) was observed. Conclusions: The results of this study suggest that palatal brushing is an effective treatment of denture stomatitis. (AU)

FAPESP's process: 12/04234-3 - Phase I clinical trial on the effect of palatal brushing on denture stomatitis
Grantee:Raphael Freitas de Souza
Support Opportunities: Regular Research Grants