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Clinical evaluation of antifungal addition to temporary soft liner in the treatment of denture stomatitis

Abstract

Antimicrobial agents incorporated into temporary denture relines have proven to be effective and viable as denture stomatitis' treatment in studies in vivo and in vitro. This therapeutic approach has the advantage of breaking the cycle of mucosal reinfection, acting on them through the incorporated drugs, which are released gradually over the useful life of these materials. It has been previously demonstrated that, within 14 days, nystatin and chlorhexidine diacetate incorporated into a temporary reliner (Trusoft) were the drugs that had minimal inhibitory concentrations (MICs) for C. albicans biofilm. Furthermore, it was observed that the addition of these MIC drugs resulted in no deleterious effects on the structural, physical and mechanical properties of the material. Despite these advantages, there are no studies with patients on effective incorporation of antifungal MICs in temporary denture reliner as method for denture stomatitis' treatment. Thus, the objective of the present study was to clinically evaluate the addition MICs of antifungal agents for C. albicans biofilm (nystatin and chlorhexidine) on the temporary resilient materials (Trusoft) in denture stomatitis' treatment. Sixty patients with denture stomatitis and users of at least one upper complete denture (CD) will be divided into four groups according to the treatment (n=15): Positive control: conventional topical antifungal agent (Nystatin oral suspension); General control: relining the upper CD with Trusoft; Nis Group: relining the upper CD with Trusoft containing Nystatin in its MIC and CLX Group: relining the upper CD with Trusoft containing the chlorhexidine diacetate in its MCI. The effectiveness of treatments will be evaluated by cytological smear, mycological quantitative cultures obtained from the inner surface of the CD and palatal mucosa of all patients before and after treatment and 15 and 30 days after its suspension. For clinical assessment, palatal photographs will be obtained of all patients at each visit. The data will be analyzed statistically (±=5%). (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMPOS SUGIO, CAROLINA YOSHI; MAIA NEVES GARCIA, AMANDA APARECIDA; ALBACH, THAIS; MORAES, GUSTAVO SIMAO; BONFANTE, ESTEVAM AUGUSTO; URBAN, VANESSA MIGLIORINI; NEPPELENBROEK, KARIN HERMANA. Candida-Associated Denture Stomatitis and Murine Models: What Is the Importance and Scientific Evidence?. JOURNAL OF FUNGI, v. 6, n. 2, . (17/07314-1, 17/22996-1)
MORAES, GUSTAVO S.; CACHOEIRA, VICTORIA S.; ALVES, FERNANDA M. C.; KIRATCZ, FALYNE; ALBACH, THAIS; BUENO, MIRIAN G.; NEPPELENBROEK, KARIN H.; URBAN, VANESSA M.. Is there an optimal method to detach Candida albicans biofilm from dental materials?. Journal of Medical Microbiology, v. 70, n. 10, . (17/07314-1)
FALCAO PROCOPIO, ANDREA LEMOS; LARA, VANESSA SOARES; PORTO, VINICIUS CARVALHO; SOARES, SIMONE; FERNANDES, MARIA HELENA; URBAN, VANESSA MIGLIORINI; NEPPELENBROEK, KARIN HERMANA. Resilient liner modified by antimicrobials for denture stomatitis treatment: A randomized controlled trial. Journal of Dentistry, v. 126, p. 9-pg., . (17/07314-1)
MORAES, GUSTAVO SIMAO; ALBACH, THAIS; SUGIO, CAROLINA YOSHI CAMPOS; CACHOEIRA, VICTORIA SCHLUMBERGER; KIRATCZ, FALYNE; CLAUDINO, MARCELA; CAMPAGNOLI, EDUARDO BAUML; POCHAPSKI, MARCIA THAIS; DOS SANTOS, FABIO ANDRE; NEPPELENBROEK, KARIN HERMANA; et al. A novel rat model of denture stomatitis and the role of antibiotics in the development of the disease. Medical Mycology, v. 60, n. 12, p. 11-pg., . (17/07314-1, 17/22996-1)
MORAES, GUSTAVO SIMAO; ALBACH, THAIS; RAMOS, ISABELLA ESSER; KOPACHESKI, MARIANA GOMES; CACHOEIRA, VICTORIA SCHLUMBERGER; CAMPOS SUGIO, CAROLINA YOSHI; GALVAO ARRAIS, CESAR AUGUSTO; NEPPELENBROEK, KARIN HERMANA; URBAN, VANESSA MIGLIORINI. A novel acrylic resin palatal device contaminated with Candida albicans biofilm for denture stomatitis induction in Wistar rats. Journal of Applied Oral Science, v. 29, . (17/22996-1, 17/07314-1)
MORAES, GUSTAVO S.; ALBACH, THAIS; SUGIO, CAROLINA Y. C.; DE OLIVEIRA, FABIO B.; NEPPELENBROEK, KARIN H.; URBAN, VANESSA M.. Experimental animal models for denture stomatitis: A methodological review. LABORATORY ANIMALS, v. 56, n. 4, p. 13-pg., . (17/07314-1, 17/22996-1)
URBAN, AMANDA MIGLIORINI; MORIKAVA, FRANCINE SUMIE; SCHOEFFEL, AMANDA CRISTINA; NOVATSKI, ANDRESSA; MORAES, GUSTAVO SIMAO; CACHOEIRA, VICTORIA SCHLUMBERGER; MATIOLI, GRACIETTE; ITO, CARMEN ANTONIA SANCHES; FERRARI, PRISCILEILA COLERATO; NEPPELENBROEK, KARIN HERMANA; et al. Characterization, Antifungal Evaluation against Candida spp. Strains and Application of Nystatin: & beta;-cyclodextrin Inclusion Complexes. CURRENT DRUG DELIVERY, v. 20, n. 10, p. 14-pg., . (17/07314-1)
GARCIA, CINDY RUIZ; UEDA, THAIS YUMI; DA SILVA, RAFAELA ALVES; CANO, ISADORA PRADO; SALDANHA, LUIZ LEONARDO; DOKKEDAL, ANNE LIGIA; PORTO, VINICIUS CARVALHO; URBAN, VANESSA MIGLIORINI; NEPPELENBROEK, KARIN HERMANA. Effect of denture liners surface modification with Equisetum giganteum and Punica granatum on Candida albicans biofilm inhibition. THERAPEUTIC DELIVERY, v. 13, n. 3, p. 10-pg., . (17/07314-1, 16/08702-2)

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