Involvement of miRNAs and Cell-Secreted Vesicles in Mammalian Ovarian Antral Follicle Development

Autor(es)

da Silveira, Juliano C. ^[1] ; de Andrade, Gabriella M. ^[1] ; Nogueira, Marcelo F. G. ^[2] ; Meirelles, Flavio V. ^[1] ; Perecin, Felipe ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, BR-13635900 Pirassununga, SP - Brazil

^[2] Univ Sao Paulo State, Fac Sci & Letters, Dept Biol Sci, Assis, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: REPRODUCTIVE SCIENCES; v. 22, n. 12, p. 1474-1483, DEC 2015.
• Citações Web of Science: 12

Resumo

Ovarian follicular development is a controlled series of events culminating with an ovulatory or atretic follicle. MicroRNAs (miRNAs) are small noncoding RNAs involved in translational regulation of genes in different developmental processes. Deletion of Dicer in mice ovaries demonstrated the importance of miRNAs in reproduction, which led to infertility. The miRNAs were thought to act only within host cells; however, these molecules are also present in cell-secreted vesicles. These vesicles are present in body fluids such as milk, serum, and ovarian follicular fluid. Vesicles are secreted in extracellular fluids and travel from donor to target cells, mediating transfer of bioactive material. Herein we discuss the role of hormonal-regulated miRNAs within different ovarian follicular cells as well as cell-secreted vesicles participation in mammalian ovarian follicular fluid. Furthermore, we discuss the possibility of miRNAs transference mediated by cell-secreted vesicles present in ovarian follicular fluid, increasing the versatility of miRNA functions during antral follicle development. (AU)

• Processo FAPESP: 13/10473-3 - Análise da função de vesículas secretadas em líquido folicular na maturação de oócitos e no controle de mudanças epigenéticas
• Beneficiário: Juliano Coelho da Silveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/50533-2 - GIFT: melhoramento genômico de características relacionadas com a fertilização em gado bovino dinamarquês e brasileiro
• Beneficiário: Marcelo Fábio Gouveia Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/08135-2 - CTC - Centro de Terapia Celular
• Beneficiário: Dimas Tadeu Covas
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs