Mechanisms of Self-Sustained Oscillatory States in Hierarchical Modular Networks with Mixtures of Electrophysiological Cell Types

Autor(es)

Tomov, Peter ^[1] ; Pena, Rodrigo F. O. ^{[2, 3]} ; Roque, Antonio C. ^[3] ; Zaks, Michael A. ^[4]

Afiliação do(s) autor(es)

^[1] Humboldt Univ, Inst Math, D-10099 Berlin - Germany

^[2] Humboldt Univ, Inst Phys, D-10099 Berlin - Germany

^[3] Univ Sao Paulo, Dept Phys, Sch Philosophy Sci & Letters Ribeirao Preto, Lab Sistemas Neurais, Sao Paulo - Brazil

^[4] Univ Potsdam, Inst Phys & Astron, Potsdam - Germany

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN COMPUTATIONAL NEUROSCIENCE; v. 10, MAR 23 2016.
• Citações Web of Science: 3

Resumo

In a network with a mixture of different electrophysiological types of neurons linked by excitatory and inhibitory connections, temporal evolution leads through repeated epochs of intensive global activity separated by intervals with low activity level. This behavior mimics ``up{''} and ``down{''} states, experimentally observed in cortical tissues in absence of external stimuli. We interpret global dynamical features in terms of individual dynamics of the neurons. In particular, we observe that the crucial role both in interruption and in resumption of global activity is played by distributions of the membrane recovery variable within the network. We also demonstrate that the behavior of neurons is more influenced by their presynaptic environment in the network than by their formal types, assigned in accordance with their response to constant current. (AU)

• Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
• Beneficiário: Oswaldo Baffa Filho
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 15/09916-3 - Análise da dinâmica de modelos corticais com populações de células heterogêneas
• Beneficiário: Rodrigo Felipe de Oliveira Pena
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
• Processo FAPESP: 13/25667-8 - Mecanismos de propagação de atividade epileptiforme em um modelo cortical de grande porte
• Beneficiário: Rodrigo Felipe de Oliveira Pena
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto