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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mechanisms of Self-Sustained Oscillatory States in Hierarchical Modular Networks with Mixtures of Electrophysiological Cell Types

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Tomov, Peter [1] ; Pena, Rodrigo F. O. [2, 3] ; Roque, Antonio C. [3] ; Zaks, Michael A. [4]
Total Authors: 4
[1] Humboldt Univ, Inst Math, D-10099 Berlin - Germany
[2] Humboldt Univ, Inst Phys, D-10099 Berlin - Germany
[3] Univ Sao Paulo, Dept Phys, Sch Philosophy Sci & Letters Ribeirao Preto, Lab Sistemas Neurais, Sao Paulo - Brazil
[4] Univ Potsdam, Inst Phys & Astron, Potsdam - Germany
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 3

In a network with a mixture of different electrophysiological types of neurons linked by excitatory and inhibitory connections, temporal evolution leads through repeated epochs of intensive global activity separated by intervals with low activity level. This behavior mimics ``up{''} and ``down{''} states, experimentally observed in cortical tissues in absence of external stimuli. We interpret global dynamical features in terms of individual dynamics of the neurons. In particular, we observe that the crucial role both in interruption and in resumption of global activity is played by distributions of the membrane recovery variable within the network. We also demonstrate that the behavior of neurons is more influenced by their presynaptic environment in the network than by their formal types, assigned in accordance with their response to constant current. (AU)

FAPESP's process: 15/09916-3 - Analysis of the dynamics of cortical models with heterogeneous cell populations
Grantee:Rodrigo Felipe de Oliveira Pena
Support type: Scholarships abroad - Research Internship - Doctorate (Direct)
FAPESP's process: 13/25667-8 - Mechanisms of propagation of epileptiform activity in a large-scale cortical model
Grantee:Rodrigo Felipe de Oliveira Pena
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/07699-0 - Research, Innovation and Dissemination Center for Neuromathematics - NeuroMat
Grantee:Jefferson Antonio Galves
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC