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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence

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Moura, Luciana Monteiro [1, 2, 3] ; Kempton, Matthew [3] ; Barker, Gareth [3] ; Salum, Giovanni [4, 5] ; Gadelha, Ary [1, 2] ; Pan, Pedro Mario [1, 2] ; Hoexter, Marcelo [6] ; Gomes Del Aquilla, Marco Antonio [1, 2] ; Picon, Felipe Almeida [4, 5] ; Anes, Mauricio [4] ; Garcia Otaduy, Maria Concepcion [6] ; Amaro, Jr., Edson [6] ; Rohde, Luis Augusto [4, 5] ; McGuire, Philip [3] ; Bressan, Rodrigo Affonseca [1, 2] ; Sato, Joao Ricardo [7] ; Jackowski, Andrea Parolin [1, 2]
Número total de Autores: 17
Afiliação do(s) autor(es):
[1] Fed Univ Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psychiat, Rua Borges Lagoa 570, 1 Andar, BR-04039032 Sao Paulo - Brazil
[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, London WC2R 2LS - England
[4] CNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo - Brazil
[5] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Psychiat, BR-90046900 Porto Alegre, RS - Brazil
[6] Univ Sao Paulo, Lab Magnet Resonance Neuroradiol, LIM 44, Inst & Dept Radiol, Sao Paulo - Brazil
[7] Univ Fed ABC, Ctr Math Computat & Cognit, Santo Andre - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: MAGNETIC RESONANCE IMAGING; v. 34, n. 4, p. 529-534, MAY 2016.
Citações Web of Science: 8
Resumo

In the last decade, several studies have described the typical brain white matter maturation in children and adolescents. Diffusion tensor imaging (DTI) is the most frequent MRI technique used to investigate the structural changes across development. However, few previous studies have used the magnetization transfer ratio (MTR), which gives a closer measure of myelin content. Here, we employed both techniques for the same sample of 176 typically developing children from 7 to 14 years of age. We investigated the associations between DTI parameters and MTR measure, to assess the myelination in the brain in development. Secondly, we investigated age-effects on DTI parameters (fractional anisotropy, axial, radial and mean diffusivities) and MTR. No significant correlations between MTR and DTI parameters were observed. In addition, a significant age-effect was detected for DTI data but was not visible for MTR data. Thereby, changes in white matter at this age might be primarily correlated with microstructural changes. (C) 2015 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 13/00506-1 - Séries temporais, ondaletas e análise de dados funcionais
Beneficiário:Pedro Alberto Morettin
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/08531-5 - Coorte de alto risco para transtornos psiquiátricos na infância: seguimento de neuroimagem após 3 anos
Beneficiário:Andrea Parolin Jackowski
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/10498-6 - Aprendizado de máquina em neuroimagem: desenvolvimento de métodos e aplicações clínicas em transtornos psiquiátricos
Beneficiário:João Ricardo Sato
Modalidade de apoio: Auxílio à Pesquisa - Regular