Environmentally Safe Condition for the Synthesis of Aryl and Alkyl Sulfonyl Hydrazones via One-Pot Reaction

Autor(es)

Cunha, Micael R. ^[1] ; Tavares, Mauricio T. ^[1] ; Carvalho, Camila F. ^[1] ; Silva, Nuno A. T. ^[1] ; Souza, Alfredo D. F. ^[1] ; Pereira, Gustavo J. V. ^[1] ; Ferreira, Fabio F. ^[2] ; Parise-Filho, Roberto ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Lab Design & Synth Bioact Subst LAPESSB, Fac Pharmaceut Sci, Prof Lineu Prestes Ave, 580, Bl 13, BR-05508020 Sao Paulo, SP - Brazil

^[2] Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, BR-09210580 Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ACS SUSTAINABLE CHEMISTRY & ENGINEERING; v. 4, n. 4, p. 1899-1905, APR 2016.
• Citações Web of Science: 6

Resumo

Sulfonyl hydrazones were synthesized by one pot reaction using sulfonyl chlorides, hydrazine hydrate and aldehydes under mild, cheap and environmental safe conditions. The optimized reaction afforded nine products with yields higher than 94% and four products with yields between 34% and 83%. Also, this paper reports, for the first time, the reduction of hydrazine amount (1.2 equiv) in sulfonyl hydrazones synthesis, presenting an excellent perspective to the sustainable production of new drug candidates. (AU)

• Processo FAPESP: 13/18160-4 - Candidatos a novos antineoplásicos: planejamento, síntese e avaliação da atividade antitumoral de análogos capsaicinóides e capsinóides, com vistas à elucidação do mecanismo de ação
• Beneficiário: Roberto Parise Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular