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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Environmentally Safe Condition for the Synthesis of Aryl and Alkyl Sulfonyl Hydrazones via One-Pot Reaction

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Author(s):
Cunha, Micael R. [1] ; Tavares, Mauricio T. [1] ; Carvalho, Camila F. [1] ; Silva, Nuno A. T. [1] ; Souza, Alfredo D. F. [1] ; Pereira, Gustavo J. V. [1] ; Ferreira, Fabio F. [2] ; Parise-Filho, Roberto [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Lab Design & Synth Bioact Subst LAPESSB, Fac Pharmaceut Sci, Prof Lineu Prestes Ave, 580, Bl 13, BR-05508020 Sao Paulo, SP - Brazil
[2] Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ACS SUSTAINABLE CHEMISTRY & ENGINEERING; v. 4, n. 4, p. 1899-1905, APR 2016.
Web of Science Citations: 6
Abstract

Sulfonyl hydrazones were synthesized by one pot reaction using sulfonyl chlorides, hydrazine hydrate and aldehydes under mild, cheap and environmental safe conditions. The optimized reaction afforded nine products with yields higher than 94% and four products with yields between 34% and 83%. Also, this paper reports, for the first time, the reduction of hydrazine amount (1.2 equiv) in sulfonyl hydrazones synthesis, presenting an excellent perspective to the sustainable production of new drug candidates. (AU)

FAPESP's process: 13/18160-4 - Novel anticancer candidates: design, synthesis, antitumoral activity and mode of action of novel capsaicinoids and capsinoids analogues
Grantee:Roberto Parise Filho
Support Opportunities: Regular Research Grants