Solubility of protocatechuic acid, sinapic acid and chrysin in supercritical carbon dioxide

Autor(es)

Paula, Julia T. ^[1] ; Sousa, Ilza M. O. ^[2] ; Foglio, Mary A. ^[3] ; Cabral, Fernando A. ^[1]

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Dept Food Engn, BR-13083862 Campinas, SP - Brazil

^[2] State Univ Campinas UNICAMP, Chem Biol & Agr Pluridisciplinary Res Ctr CPQBA, BR-13083970 Campinas, SP - Brazil

^[3] State Univ Campinas UNICAMP, Fac Pharmaceut Sci, BR-13081970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF SUPERCRITICAL FLUIDS; v. 112, p. 89-94, JUN 2016.
• Citações Web of Science: 10

Resumo

Solubility data of some phenolic compounds of industrial interest, such as protocatechuic acid (3,4-dihydroxybenzoic acid), chrysin (5,7-dihydroxyflavone) and sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid) in supercritical carbon dioxide were determined at pressures of 200, 300 and 400 bar and temperatures of 40, 50 and 60 degrees C. Experimental data were correlated with semi-empirical Chrastil model and thermodynamic modeling using the Peng-Robinson equation of state with classical mixing rule. The critical properties, acentric factor, and vapor pressure of these compounds were estimated by group contribution methods. The solubility values followed a similar tendency, with higher solubility with increasing temperature and pressure, and no crossover pressure in the range studied. However, a crossover pressure around 150 bar was observed when extrapolating the solubility data by the Chrastil equation, which is in agreement with values reported in the literature for phenolic compounds, thereby indicating the consistency of the solubility experimental data. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/51317-1 - Desenvolvimento de produtos e processos por tecnologia supercrítica: construção de uma unidade multipropósito para obtenção de extratos de interesse industrial
• Beneficiário: Fernando Antonio Cabral
• Modalidade de apoio: Auxílio à Pesquisa - Regular