HIV-1 gp120 T-Cell Responses Correspond to Infection Outcomes in the Global iPrEx Chemoprophylaxis Trial

Autor(es)

Kuebler, Peter J. ^[1] ; Shaw, Brian I. ^[1] ; Leadabrand, Kaitlyn S. ^[1] ; Mehrotra, Megha L. ^[2] ; Grant, Robert M. ^{[3, 2]} ; Kallas, Esper G. ^[4] ; Nixon, Douglas F. ^[5]

Afiliação do(s) autor(es)

^[1] Univ Calif San Francisco, Div Expt Med, San Francisco, CA 94143 - USA

^[2] Gladstone Inst, San Francisco, CA - USA

^[3] Univ Calif San Francisco, Dept Med, San Francisco, CA - USA

^[4] Univ Sao Paulo, Div Clin Immunol & Allergy, Sao Paulo - Brazil

^[5] George Washington Univ, Dept microbiol Immunol & Trop Med, Washington, DC - USA

• Tipo de documento: Artigo Científico
• Fonte: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES; v. 72, n. 2, p. 184-188, JUN 1 2016.
• Citações Web of Science: 1

Resumo

Association of HIV-1-specific T-cell responses to infection risk in seronegative individuals is controversial. We quantified and phenotypically characterized gp120-specific T-cell responses in HIV-1 exposed, but uninfected subjects enrolled in the global Pre-exposure Prophylaxis Initiative (iPrEx) chemoprophylaxis trial. IFN gamma ELISpot responses were detected in 24% of subjects irrespective of infection outcome. HIV-1 gp120 envelope-specific T-cell responses were more uniformly IFN-gamma+TNF-alpha+Mip-1 beta+ in persistently seronegative subjects relative to subjects who later seroconverted (median frequency of 76.5% and 66.5%, respectively). IFNg responses targeted the V2 loop for subjects who remained seronegative. HIV-1 gp120 envelope V2 loop-specific CD8(+) T-cell responses may help to protect against HIV-1 acquisition. (AU)

• Processo FAPESP: 04/15856-9 - Análise prospectiva das características virológicas e imunológicas em indivíduos com infecção recente pelo HIV-1 das cidades de São Paulo e Santos, SP
• Beneficiário: Ricardo Sobhie Diaz
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 10/05845-0 - Resposta imune celular em doenças infecciosas e imunodeficiências primárias
• Beneficiário: Esper Georges Kallás
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional