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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

HIV-1 gp120 T-Cell Responses Correspond to Infection Outcomes in the Global iPrEx Chemoprophylaxis Trial

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Author(s):
Kuebler, Peter J. [1] ; Shaw, Brian I. [1] ; Leadabrand, Kaitlyn S. [1] ; Mehrotra, Megha L. [2] ; Grant, Robert M. [3, 2] ; Kallas, Esper G. [4] ; Nixon, Douglas F. [5]
Total Authors: 7
Affiliation:
[1] Univ Calif San Francisco, Div Expt Med, San Francisco, CA 94143 - USA
[2] Gladstone Inst, San Francisco, CA - USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA - USA
[4] Univ Sao Paulo, Div Clin Immunol & Allergy, Sao Paulo - Brazil
[5] George Washington Univ, Dept microbiol Immunol & Trop Med, Washington, DC - USA
Total Affiliations: 5
Document type: Journal article
Source: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES; v. 72, n. 2, p. 184-188, JUN 1 2016.
Web of Science Citations: 1
Abstract

Association of HIV-1-specific T-cell responses to infection risk in seronegative individuals is controversial. We quantified and phenotypically characterized gp120-specific T-cell responses in HIV-1 exposed, but uninfected subjects enrolled in the global Pre-exposure Prophylaxis Initiative (iPrEx) chemoprophylaxis trial. IFN gamma ELISpot responses were detected in 24% of subjects irrespective of infection outcome. HIV-1 gp120 envelope-specific T-cell responses were more uniformly IFN-gamma+TNF-alpha+Mip-1 beta+ in persistently seronegative subjects relative to subjects who later seroconverted (median frequency of 76.5% and 66.5%, respectively). IFNg responses targeted the V2 loop for subjects who remained seronegative. HIV-1 gp120 envelope V2 loop-specific CD8(+) T-cell responses may help to protect against HIV-1 acquisition. (AU)

FAPESP's process: 04/15856-9 - Prospective analysis of the virological and immunological characteristics in individuals with recent HIV-1 infection in the cities of São Paulo and Santos
Grantee:Ricardo Sobhie Diaz
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 10/05845-0 - Cellular immune responses in infectious diseases and primary immunodeficiencies
Grantee:Esper Georges Kallás
Support Opportunities: Research Grants - Visiting Researcher Grant - International