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Prevalency of Brazilian strain B-GWGR and the diversity of V3 region among slow progressors with HIV-1 infection

Grant number: 14/22418-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2015
Effective date (End): April 30, 2016
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal researcher:Jorge Simão do Rosário Casseb
Grantee:Alline Stach de Souza
Home Institution: Instituto de Medicina Tropical de São Paulo (IMT). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The HIV-1 diversity in Brazil, where several subtypes such as B, C and F has been ascribing, with a predominance of subtype B. Based on the diversity of the V3 loop of the viral envelope (gp120), a variant of subtype occurs, denominated B -GWGR. In previous results, this Brazilian variant that has the amino acid tryptophan in place of proline, has less pathogenic sequence that normally also found in Europe and USA, called B-GPGR. The natural history of HIV-1 around 1-3% of patients exhibit a slower rate with minimal decrease of immunity responsive reflected for long time of infection (> 7-10 years) control or low viral load and count lymphocytes T CD4 + stable (above 500 cells / mm 3) as well as control the disease without use of antiretroviral drugs named long term non-progressors (LTNP). After identification of 10 individuals already mapped using sequencing techniques and the ELISPOT for quantifying interferon-gamma, We will be assay cellular immune response in these patients and whether there is involvement in people who do not progress naturally with natural chronic infection that have the viral genotype B-GWGR.

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