Connexins, Pannexins, and Their Channels in Fibroproliferative Diseases

Autor(es)

Cogliati, Bruno ^[1] ; Mennecier, Gregory ^[1] ; Willebrords, Joost ^[2] ; Da Silva, Tereza Cristina ^[1] ; Maes, Michael ^[2] ; Alves Pereira, Isabel Veloso ^[1] ; Yanguas, Sara Crespo ^[2] ; Hernandez-Blazquez, Francisco Javier ^[3] ; Zaidan Dagli, Maria Lucia ^[1] ; Vinken, Mathieu ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Av Prof Dr Orlando Marques Paiva 87, BR-05508270 Sao Paulo - Brazil

^[2] Vrije Univ Brussel, Fac Med & Pharm, Dept Vitro Toxicol & Dermatocosmetol, Brussels - Belgium

^[3] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Surg, BR-05508270 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Membrane Biology; v. 249, n. 3, p. 199-213, JUN 2016.
• Citações Web of Science: 6

Resumo

Cellular and molecular mechanisms of wound healing, tissue repair, and fibrogenesis are established in different organs and are essential for the maintenance of function and tissue integrity after cell injury. These mechanisms are also involved in a plethora of fibroproliferative diseases or organ-specific fibrotic disorders, all of which are associated with the excessive deposition of extracellular matrix components. Fibroblasts, which are key cells in tissue repair and fibrogenesis, rely on communicative cellular networks to ensure efficient control of these processes and to prevent abnormal accumulation of extracellular matrix into the tissue. Despite the significant impact on human health, and thus the epidemiologic relevance, there is still no effective treatment for most fibrosis-related diseases. This paper provides an overview of current concepts and mechanisms involved in the participation of cellular communication via connexin-based pores as well as pannexin-based channels in the processes of tissue repair and fibrogenesis in chronic diseases. Understanding these mechanisms may contribute to the development of new therapeutic strategies to clinically manage fibroproliferative diseases and organ-specific fibrotic disorders. (AU)

• Processo FAPESP: 13/50420-6 - Canais de conexina e panexina como alvos terapêuticos e biomarcadores nas doenças hepáticas aguda e crônica
• Beneficiário: Mathieu Frederick Alexander Vinken
• Modalidade de apoio: Auxílio à Pesquisa - Programa SPEC
• Processo FAPESP: 05/59583-9 - Participação das conexinas 43 e 32 no desenvolvimento da fibrose hepática: estudo em camundongos geneticamente modificados
• Beneficiário: Bruno Cogliati
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto