| Texto completo | |
| Autor(es): Mostrar menos - |
Betiol, Julio C.
[1, 2]
;
Sichero, Laura
[1, 2, 3]
;
de Olival Costa, Henrique O.
[4]
;
de Matos, Leandro L.
[5]
;
Andreoli, Maria A.
[6]
;
Ferreira, Silvaneide
[1, 2]
;
Faraj, Sheila F.
[7]
;
de Mello, Evandro S.
[7]
;
Sobrinho, Joao S.
[1, 2]
;
Brandao, Lenine G.
[5]
;
Cernea, Claudio R.
[5]
;
Kulcsar, Marco A.
[5]
;
Pinto, Fabio R.
[5]
;
Goncalves, Antonio J.
[8]
;
Menezes, Marcelo B.
[8]
;
Silva, Leonardo
[4]
;
Rossi, Lia M.
[4]
;
Lima Nunes, Rafaella A.
[6]
;
Termini, Lara
[6]
;
Villa, Luisa L.
[9, 1, 2, 6]
Número total de Autores: 20
|
| Afiliação do(s) autor(es): | [1] ICESP, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Mol Biol Lab, Hosp Clin, Ctr Translat Res Oncol, Inst Canc Estado Sao Paulo, Sao Paulo - Brazil
[3] Ctr Translat Oncol ICESP, Av Dr Arnaldo 251, 8 Andar, BR-01246000 Sao Paulo, SP - Brazil
[4] Sch Med FCMSCSP, Dept Otolaringol, Santa Casa Sao Paulo, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Med, Dept Head & Neck Surg, Sao Paulo - Brazil
[6] Sch Med FCMSCSP, HPV Inst, Santa Casa Sao Paulo, Sao Paulo - Brazil
[7] Canc Inst Sao Paulo ICESP, Dept Pathol, Sao Paulo - Brazil
[8] Sch Med FCMSCSP, Dept Surg, Santa Casa Sao Paulo, Sao Paulo - Brazil
[9] Univ Sao Paulo, Sch Med, Dept Radiol & Oncol, Sao Paulo - Brazil
Número total de Afiliações: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INFECTIOUS AGENTS AND CANCER; v. 11, MAY 4 2016. |
| Citações Web of Science: | 5 |
| Resumo | |
Background: Human papillomavirus (HPV) prevalence in head and neck squamous cell carcinomas (HNSCC) diverges geographically. The reliability of using p16(INK4a) expression as a marker of viral infection is controversial in HNSCC. We evaluated HPV types and HPV-16 variants prevalence, and p16(INK4a) expression in HNSCC specimens provided by two different Institutions in Sao Paulo. Methods: HPV DNA from formalin-fixed specimens was accessed by Inno-LiPA, HPV-16 variants by PCR-sequencing, and p16(INK4a) protein levels by immunohistochemistry. Results: Overall, HPV DNA was detected among 19.4 % of the specimens (36/186). Viral prevalence was higher in the oral cavity (25.0 %, 23/92) then in other anatomical sites (oropharynx 14,3 %, larynx 13.7 %) when samples from both Institutions were analyzed together. HPV prevalence was also higher in the oral cavity when samples from both Institutions were analyzed separately. HPV-16 was the most prevalent type identified in 69.5 % of the HPV positive smaples and specimens were assigned into Asian-American (57.2 %) or European (42.8 %) phylogenetic branches. High expression of p16(INK4a) was more common among HPV positive tumors. Conclusion: Our results support a role for HPV-16 in a subset of HNSCC. (AU) | |
| Processo FAPESP: | 12/01513-9 - Diversidade de HPV e Risco de Câncer |
| Beneficiário: | Julio Cesar Betiol |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 08/57889-1 - Instituto de Ciência e Tecnologia para o Estudo das Doenças Associadas ao Papilomavírus |
| Beneficiário: | Luisa Lina Villa |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 11/09616-9 - Diversidade de HPV e risco de câncer |
| Beneficiário: | Luisa Lina Villa |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |