Multiscale entropy analysis of heart rate variability in heart failure, hypertensive, and sinoaortic-denervated rats: classical and refined approaches

Autor(es)

Virgilio Silva, Luiz Eduardo ; Lataro, Renata Maria ; Castania, Jaci Airton ; Aguiar da Silva, Carlos Alberto ; Valencia, Jose Fernando ; Murta, Jr., Luiz Otavio ; Salgado, Helio Cesar ; Fazan, Jr., Rubens ; Porta, Alberto

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY; v. 311, n. 1, p. R150-R156, JUL 1 2016.
• Citações Web of Science: 15

Resumo

The analysis of heart rate variability (HRV) by nonlinear methods has been gaining increasing interest due to their ability to quantify the complexity of cardiovascular regulation. In this study, multiscale entropy (MSE) and refined MSE (RMSE) were applied to track the complexity of HRV as a function of time scale in three pathological conscious animal models: rats with heart failure (HF), spontaneously hypertensive rats (SHR), and rats with sinoaortic denervation (SAD). Results showed that HF did not change HRV complexity, although there was a tendency to decrease the entropy in HF animals. On the other hand, SHR group was characterized by reduced complexity at long time scales, whereas SAD animals exhibited a smaller short- and long-term irregularity. We propose that short time scales (1 to 4), accounting for fast oscillations, are more related to vagal and respiratory control, whereas long time scales (5 to 20), accounting for slow oscillations, are more related to sympathetic control. The increased sympathetic modulation is probably the main reason for the lower entropy observed at high scales for both SHR and SAD groups, acting as a negative factor for the cardiovascular complexity. This study highlights the contribution of the multiscale complexity analysis of HRV for understanding the physiological mechanisms involved in cardiovascular regulation. (AU)

• Processo FAPESP: 13/20549-7 - Avanços na regulação cardiocirculatória em condições fisiológica e fisiopatológica
• Beneficiário: Helio Cesar Salgado
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 11/12460-0 - Efeitos dos bloqueios, central e periférico, da acetilcolinesterase na função cardiocirculatória e na inflamação observada em ratos espontaneamente hipertensos (SHR)
• Beneficiário: Renata Maria Lataro
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado