Behavioral sensitization to ethanol: Neural basis and factors that influence its acquisition and expression

Autor(es)

Camarini, Rosana ; Pautassi, Ricardo Marcos

• Tipo de documento: Artigo de Revisão
• Fonte: Brain Research Bulletin; v. 125, p. 53-78, JUL 2016.
• Citações Web of Science: 22

Resumo

Ethanol-induced behavioral sensitization (EBS) was first described in 1980, approximately 10 years after the phenomenon was described for psychostimulants. Ethanol acts on gamma-aminobutyric acid (GABA) and glutamate receptors as an allosteric agonist and antagonist, respectively, but it also affects many other molecular targets. The multiplicity of factors involved in the behavioral and neurochemical effects of ethanol and the ensuing complexity may explain much of the apparent disparate results, found across different labs, regarding ethanol-induced behavioral sensitization. Although the mesocorticolimbic dopamine system plays an important role in EBS, we provide evidence of the involvement of other neurotransmitter systems, mainly the glutamatergic, GABAergic, and opioidergic systems. This review also analyses the neural underpinnings (e.g., induction of cellular transcription factors such as cyclic adenosine monophosphate response element binding protein and growth factors, such as the brain derived neurotrophic factor) and other factors that influence the phenomenon, including age, sex, dose, and protocols of drug administration. One of the reasons that make EBS an attractive phenomenon is the assumption, firmly based on empirical evidence, that EBS and addiction-related processes have common molecular and neural basis. Therefore, EBS has been used as a model of addiction processes. We discuss the association between different measures of ethanol-induced reward and EBS. Parallels between the pharmacological basis of EBS and acute motor effects of ethanol are also discussed. (C) 2016 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 12/10260-7 - Análise das vias de ativação do CREB em camungondos adolescentes e adultos tratados com cocaína.
• Beneficiário: Rosana Camarini
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/07871-6 - Eixo Imune-Pineal: produção endócrina e parácrina de melatonina em condições de injúria
• Beneficiário: Regina Pekelmann Markus
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 10/12968-1 - Influência do enriquecimento ambiental sobre efeitos comportamentais e neuroquímicos induzidos pelo etanol
• Beneficiário: Rosana Camarini
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/53848-6 - Efeitos do tratamento prolongado com etanol sobre a sinalizacao da via do ampc em camundongos adolescentes e adultos.
• Beneficiário: Rosana Camarini
• Linha de fomento: Auxílio à Pesquisa - Regular