Inheritance of the Bantu/Benin haplotype causes less severe hemolytic and oxidative stress in sickle cell anemia patients treated with hydroxycarbamide

Autor(es)

Okumura, Jessika V. ; Silva, Danilo G. H. ; Torres, Lidiane S. ; Belini-Junior, Edis ; Barberino, Willian M. ; Oliveira, Renan G. ; Carrocini, Gisele C. S. ; Gelaleti, Gabriela B. ; Lobo, Clarisse L. C. ; Bonini-Domingos, Claudia R.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF HUMAN GENETICS; v. 61, n. 7, p. 605-611, JUL 2016.
• Citações Web of Science: 1

Resumo

Beta S-globin gene cluster haplotypes (beta(S)-haplotypes) can modulate the response to hydroxycarbamide (HC) treatment in sickle cell anemia (SCA) patients. In Brazil, the most common haplotypes are Bantu and Benin, and both confer a poor prognosis for patients when untreated with HC. We evaluated oxidative and hemolytic biomarkers in 48 SCA patients undergoing HC treatment separated in three subgroups: Bantu/Bantu, Bantu/Benin and Benin/Benin haplotype. On the basis of reduced haptoglobin (HP) levels, patients with Bantu/Bantu haplotypes had 3.0% higher hemolysis degree when compared with those with Bantu/Benin haplotypes (P=0.01). The Benin/Benin patients had 53.6% greater lipid peroxidation index than the Bantu/Bantu patients (P=0.01) because of evaluated thiobarbituric acid reactive species levels. The Bantu/Benin subgroup had intermediate levels of hemolytic and oxidative stress markers compared with the homozygous subgroups. Through strict inclusion criteria adopted, as well as consolidated and well-described hemolytic and the oxidative parameters evaluated, we suggest a haplotype-interaction response to HC treatment mediated by a `balance' between the genetic factors of each haplotype studied. (AU)

• Processo FAPESP: 11/14168-5 - Modulação pelo haplótipo Bantu da resposta ao uso de hidroxiuréia em anemia falciforme
• Beneficiário: Jéssika Viviani Okumura
• Linha de fomento: Bolsas no Brasil - Mestrado