| Full text | |
| Author(s): |
Okumura, Jessika V.
;
Silva, Danilo G. H.
;
Torres, Lidiane S.
;
Belini-Junior, Edis
;
Barberino, Willian M.
;
Oliveira, Renan G.
;
Carrocini, Gisele C. S.
;
Gelaleti, Gabriela B.
;
Lobo, Clarisse L. C.
;
Bonini-Domingos, Claudia R.
Total Authors: 10
|
| Document type: | Journal article |
| Source: | JOURNAL OF HUMAN GENETICS; v. 61, n. 7, p. 605-611, JUL 2016. |
| Web of Science Citations: | 1 |
| Abstract | |
Beta S-globin gene cluster haplotypes (beta(S)-haplotypes) can modulate the response to hydroxycarbamide (HC) treatment in sickle cell anemia (SCA) patients. In Brazil, the most common haplotypes are Bantu and Benin, and both confer a poor prognosis for patients when untreated with HC. We evaluated oxidative and hemolytic biomarkers in 48 SCA patients undergoing HC treatment separated in three subgroups: Bantu/Bantu, Bantu/Benin and Benin/Benin haplotype. On the basis of reduced haptoglobin (HP) levels, patients with Bantu/Bantu haplotypes had 3.0% higher hemolysis degree when compared with those with Bantu/Benin haplotypes (P=0.01). The Benin/Benin patients had 53.6% greater lipid peroxidation index than the Bantu/Bantu patients (P=0.01) because of evaluated thiobarbituric acid reactive species levels. The Bantu/Benin subgroup had intermediate levels of hemolytic and oxidative stress markers compared with the homozygous subgroups. Through strict inclusion criteria adopted, as well as consolidated and well-described hemolytic and the oxidative parameters evaluated, we suggest a haplotype-interaction response to HC treatment mediated by a `balance' between the genetic factors of each haplotype studied. (AU) | |
| FAPESP's process: | 11/14168-5 - Bantu haplotype modulation of the response to the hydroxyurea usage in sickle cell anemia |
| Grantee: | Jéssika Viviani Okumura |
| Support Opportunities: | Scholarships in Brazil - Master |