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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Inheritance of the Bantu/Benin haplotype causes less severe hemolytic and oxidative stress in sickle cell anemia patients treated with hydroxycarbamide

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Author(s):
Okumura, Jessika V. ; Silva, Danilo G. H. ; Torres, Lidiane S. ; Belini-Junior, Edis ; Barberino, Willian M. ; Oliveira, Renan G. ; Carrocini, Gisele C. S. ; Gelaleti, Gabriela B. ; Lobo, Clarisse L. C. ; Bonini-Domingos, Claudia R.
Total Authors: 10
Document type: Journal article
Source: JOURNAL OF HUMAN GENETICS; v. 61, n. 7, p. 605-611, JUL 2016.
Web of Science Citations: 1
Abstract

Beta S-globin gene cluster haplotypes (beta(S)-haplotypes) can modulate the response to hydroxycarbamide (HC) treatment in sickle cell anemia (SCA) patients. In Brazil, the most common haplotypes are Bantu and Benin, and both confer a poor prognosis for patients when untreated with HC. We evaluated oxidative and hemolytic biomarkers in 48 SCA patients undergoing HC treatment separated in three subgroups: Bantu/Bantu, Bantu/Benin and Benin/Benin haplotype. On the basis of reduced haptoglobin (HP) levels, patients with Bantu/Bantu haplotypes had 3.0% higher hemolysis degree when compared with those with Bantu/Benin haplotypes (P=0.01). The Benin/Benin patients had 53.6% greater lipid peroxidation index than the Bantu/Bantu patients (P=0.01) because of evaluated thiobarbituric acid reactive species levels. The Bantu/Benin subgroup had intermediate levels of hemolytic and oxidative stress markers compared with the homozygous subgroups. Through strict inclusion criteria adopted, as well as consolidated and well-described hemolytic and the oxidative parameters evaluated, we suggest a haplotype-interaction response to HC treatment mediated by a `balance' between the genetic factors of each haplotype studied. (AU)

FAPESP's process: 11/14168-5 - Bantu haplotype modulation of the response to the hydroxyurea usage in sickle cell anemia
Grantee:Jéssika Viviani Okumura
Support type: Scholarships in Brazil - Master