Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Inheritance of the Bantu/Benin haplotype causes less severe hemolytic and oxidative stress in sickle cell anemia patients treated with hydroxycarbamide

Full text
Okumura, Jessika V. ; Silva, Danilo G. H. ; Torres, Lidiane S. ; Belini-Junior, Edis ; Barberino, Willian M. ; Oliveira, Renan G. ; Carrocini, Gisele C. S. ; Gelaleti, Gabriela B. ; Lobo, Clarisse L. C. ; Bonini-Domingos, Claudia R.
Total Authors: 10
Document type: Journal article
Source: JOURNAL OF HUMAN GENETICS; v. 61, n. 7, p. 605-611, JUL 2016.
Web of Science Citations: 1

Beta S-globin gene cluster haplotypes (beta(S)-haplotypes) can modulate the response to hydroxycarbamide (HC) treatment in sickle cell anemia (SCA) patients. In Brazil, the most common haplotypes are Bantu and Benin, and both confer a poor prognosis for patients when untreated with HC. We evaluated oxidative and hemolytic biomarkers in 48 SCA patients undergoing HC treatment separated in three subgroups: Bantu/Bantu, Bantu/Benin and Benin/Benin haplotype. On the basis of reduced haptoglobin (HP) levels, patients with Bantu/Bantu haplotypes had 3.0% higher hemolysis degree when compared with those with Bantu/Benin haplotypes (P=0.01). The Benin/Benin patients had 53.6% greater lipid peroxidation index than the Bantu/Bantu patients (P=0.01) because of evaluated thiobarbituric acid reactive species levels. The Bantu/Benin subgroup had intermediate levels of hemolytic and oxidative stress markers compared with the homozygous subgroups. Through strict inclusion criteria adopted, as well as consolidated and well-described hemolytic and the oxidative parameters evaluated, we suggest a haplotype-interaction response to HC treatment mediated by a `balance' between the genetic factors of each haplotype studied. (AU)

FAPESP's process: 11/14168-5 - Bantu haplotype modulation of the response to the hydroxyurea usage in sickle cell anemia
Grantee:Jéssika Viviani Okumura
Support type: Scholarships in Brazil - Master