| Grant number: | 12/02171-4 |
| Support Opportunities: | Scholarships in Brazil - Master |
| Start date: | June 01, 2012 |
| End date: | February 28, 2014 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Claudia Regina Bonini Domingos |
| Grantee: | Willian Marcel Barberino |
| Host Institution: | Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil |
Abstract Sickle Cell Anemia (SCA) is a hereditary hemolytic disease which causes complex and several clinical manifestations. The oxidative stress is one of the factors that influence the phenotype of the carrier and the processes of vascular occlusion by increasing the adhesive properties of erythrocytes, leukocytes and platelets to the endothelium. During the transformation of the erythrocyte with S hemoglobin in sickle erythrocyte among the biochemical events there is the oxidative degradation of this hemoglobin releasing degradation products, Fe 2+ and Fe 3+ complexes that attack the cell membrane resulting in lipid hydroperoxides and peroxyl and alkoxyl radicals. Among the phase II detoxifying enzymes the most studied are GSTs (GSTM1, GSTT1 and GSTP1) that may provide low enzymatic activity, affecting the body's antioxidant defenses. Considering the high incidence of AF in our country and the several clinical manifestations in patients, this study aims to investigate polymorphisms of GSTs (GSTT1, GSTM1 and GSTP1) and determine its influence on oxidative parameters - lipid peroxidation by MDA and DNA damage by micronucleus and comet in patients with AF. | |
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