Intratablet S-nitrosation: A New Approach for the Oral Administration of S-nitrosothiols as Nitric Oxide Donors

Autor(es)

Pereira de Souza, Gabriela Freitas ; de Oliveira, Marcelo Ganzarolli

• Tipo de documento: Artigo Científico
• Fonte: Journal of Pharmaceutical Sciences; v. 105, n. 1, p. 359-361, JAN 2016.
• Citações Web of Science: 5

Resumo

The primary S-nitrosothiol, S-nitroso-N-acetylcysteine (SNAC) is a nitric oxide donor with potential pharmaceutical applications for the oral treatment of hepatic steatosis and cirrhosis and for protection against gastric acidepeptic disorders. However, its low thermal stability precludes the preparation of stable dosage forms based on presynthesized SNAC. In this study, we describe an innovative strategy for the oral administration of SNAC based on its intratablet formation via the S-nitrosation reaction of its parent stable thiol, N-acetyl-L-cysteine by nitrous acid during the absorption of water by the tablet. The proposed strategy allows for the manufacturing of thermally stable oral dosage forms for the controlled release of SNAC in the enteric medium. (C) 2016 American Pharmacists Association(R). Published by Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 08/57560-0 - Efeitos do chá verde (Camellia sinensis), do cacau e de um doador de óxido nítrico na nefropatia e retinopatia diabética: papel da redução do estresse oxidativo e da inflamação e do aumento do óxido nítrico
• Beneficiário: Jose Butori Lopes de Faria
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 11/50514-5 - O efeito das interleucinas-6,-10 e -27 na perda de peso por restrição calórica
• Beneficiário: Gabriela Freitas Pereira de Souza
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado