Intratablet S-nitrosation: A New Approach for the Oral Administration of S-nitrosothiols as Nitric Oxide Donors

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Author(s):	Pereira de Souza, Gabriela Freitas ; de Oliveira, Marcelo Ganzarolli Total Authors: 2
Document type:	Journal article
Source:	Journal of Pharmaceutical Sciences; v. 105, n. 1, p. 359-361, JAN 2016.
Web of Science Citations:	5
Abstract
The primary S-nitrosothiol, S-nitroso-N-acetylcysteine (SNAC) is a nitric oxide donor with potential pharmaceutical applications for the oral treatment of hepatic steatosis and cirrhosis and for protection against gastric acidepeptic disorders. However, its low thermal stability precludes the preparation of stable dosage forms based on presynthesized SNAC. In this study, we describe an innovative strategy for the oral administration of SNAC based on its intratablet formation via the S-nitrosation reaction of its parent stable thiol, N-acetyl-L-cysteine by nitrous acid during the absorption of water by the tablet. The proposed strategy allows for the manufacturing of thermally stable oral dosage forms for the controlled release of SNAC in the enteric medium. (C) 2016 American Pharmacists Association(R). Published by Elsevier Inc. All rights reserved. (AU)

FAPESP's process:	08/57560-0 - Effects of green tea (Camellia sinensis), cocoa and nitric oxide donor on diabetic nephropathy and retinopathy: contribution of the reduction of oxidative stress and inflammation and elevation of nitric oxide
Grantee:	Jose Butori Lopes de Faria
Support Opportunities:	Research Projects - Thematic Grants