Effects of green tea (Camellia sinensis), cocoa and nitric oxide donor on diabetic nephropathy and retinopathy: contribution of the reduction of oxidative stress and inflammation and elevation of nitric oxide

• Grant number: 08/57560-0
• Support Opportunities: Research Projects - Thematic Grants
• Duration: August 01, 2009 - January 31, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Jose Butori Lopes de Faria
• Grantee: Jose Butori Lopes de Faria
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Pesquisadores principais: Marcelo Ganzarolli de Oliveira
• Associated scholarship(s): 14/03266-4 - PVA-F-127 thermosensitive nanocarriers for the photochemical nitric oxide release, BP.MS; 10/20471-0 - Is it possible to prevent the experimental diabetic retinopathy through the use of the cacao? Evaluation of antioxidant mechanisms and the bioavailability of nitric oxide, BP.DD; 10/05841-5 - Oxidative stress contribution for glomerular filtration barrier integrity in diabetic and hipertensive rats, BP.PD

Abstract

Diabetes mellitus (DM) affects about 20 million of individuals in Brazil. Roughly, a third of these individuals will develop renal and retinal diseases. Although in the last decade the understanding of the pathogenesis and treatment of these conditions has advanced considerably, the number of individuals who develop end-stage renal disease and blindness secondary to diabetes is still rising. Several lines of evidences suggest that hyperglycemia-induced oxidative stress and reduction of nitric oxide bioavailability are crucial abnormalities to the pathogenesis of diabetes nephropathy and retinopathy. It has been demonstrated that in different diseases, including diabetes, polifenol-enriched substances, such as green tea and cocoa, are able to reduce oxidative stress and increase nitric oxide bioavailability. The efficacy of these maneuvers in diabetic nephropathy and retinopathy are largely unknown. The aims of these projects are: a) to investigate the effects of green tea, cocoa and a nitric oxide donor in experimental diabetic nephropathy and retinopathy; b) to search for the mechanism by which these substances would protect renal and retinal cells from hyperglycemia; c) to test the efficacy of green tea and cocoa in patients with diabetes mellitus. (AU)

Scientific publications

(18)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DUARTE, DIEGO A.; PAPADIMITRIOU, ALEXANDROS; GILBERT, RICHARD E.; THAI, KERRI; ZHANG, YANLING; ROSALES, MARIANA A. B.; LOPES DE FARIA, JOSE B.; LOPES DE FARIA, JACQUELINE M.. Conditioned Medium from Early-Outgrowth Bone Marrow Cells Is Retinal Protective in Experimental Model of Diabetes. PLoS One, v. 11, n. 2, FEB 2 2016. (13/04331-1, 08/57560-0, 10/11514-7)

SKEFF, MARIA ADRIANA; BRITO, GERLY A. C.; DE OLIVEIRA, MARCELO G.; BRAGA, CINTIA M.; CAVALCANTE, MATHEUS M.; BALDIM, VICTOR; HOLANDA-AFONSO, ROSENILDE C.; SILVA-BOGHOSSIAN, CARINA M.; COLOMBO, ANA PAULA; RIBEIRO, RONALDO A.; et al. S-Nitrosoglutathione Accelerates Recovery from 5-Fluorouracil-Induced Oral Mucositis. PLoS One, v. 9, n. 12, DEC 5 2014. (08/57560-0)

PEIXOTO, E. B.; PAPADIMITRIOU, A.; TEIXEIRA, D. A. T.; MONTEMURRO, C.; DUARTE, D. A.; SILVA, K. C.; JOAZEIRO, P. P.; LOPES DE FARIA, J. M.; LOPES DE FARIA, J. B.. Reduced LRP6 expression and increase in the interaction of GSK3 beta with p53 contribute to podocyte apoptosis in diabetes mellitus and are prevented by green tea. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 26, n. 4, p. 416-430, APR 2015. (10/05841-5, 08/57560-0)

ROSALES, MARIANA APARECIDA B.; SILVA, KAMILA CRISTINA; DUARTE, DIEGO A.; ROSSATO, FRANCO APARECIDO; DE FARIA, JOSE B. LOPES; LOPES DE FARIA, JACQUELINE M.. Endocytosis of Tight Junctions Caveolin Nitrosylation Dependent Is Improved by Cocoa Via Opioid Receptor on RPE Cells in Diabetic Conditions. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 55, n. 9, p. 6090-6100, SEP 2014. (11/06719-1, 08/57560-0)

PESSOA, BRUNO S.; PEIXOTO, ELISA B. M. I.; PAPADIMITRIOU, ALEXANDROS; LOPES DE FARIA, JACQUELINE M.; LOPES DE FARIA, JOSE B.. Spironolactone improves nephropathy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v. 13, n. 1, p. 56-66, MAR 2012. (08/57560-0)

FARIA, ALINE M.; PAPADIRNITRIOU, ALEXANDROS; SILVA, KAMILA C.; LOPES DE FARIA, JACQUELINE M.; LOPES DE FARIA, JOSE B.. Uncoupling Endothelial Nitric Oxide Synthase Is Ameliorated by Green Tea in Experimental Diabetes by Re-establishing Tetrahydrobiopterin Levels. Diabetes, v. 61, n. 7, p. 1838-1847, JUL 2012. (08/57560-0)

ROSALES, MARIANA A. B.; SILVA, KAMILA C.; DUARTE, DIEGO A.; DE OLIVEIRA, MARCELO G.; DE SOUZA, GABRIELA F. P.; CATHARINO, RODRIGO R.; FERREIRA, MONICA S.; LOPES DE FARIA, JOSE B.; LOPES DE FARIA, JACQUELINE M.. S-Nitrosoglutathione Inhibits Inducible Nitric Oxide Synthase Upregulation by Redox Posttranslational Modification in Experimental Diabetic Retinopathy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 55, n. 5, p. 2921-2932, MAY 2014. (11/06719-1, 08/57560-0)

MARCILLI, RAPHAEL H. M.; DE OLIVEIRA, MARCELO G.. Nitric oxide-releasing poly(vinyl alcohol) film for increasing dermal vasodilation. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 116, p. 643-651, APR 1 2014. (08/57560-0)

SILVA, KAMILA C.; ROSALES, MARIANA A. B.; HAMASSAKI, DANIA E.; SAITO, KELLY C.; FARIA, ALINE M.; RIBEIRO, PATRICIA A. O.; LOPES DE FARIA, JOSE B.; LOPES DE FARIA, JACQUELINE M.. Green Tea Is Neuroprotective in Diabetic Retinopathy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 54, n. 2, p. 1325-1336, FEB 2013. (08/57560-0, 10/11514-7)

SCHANUEL, FERNANDA SEABRA; RAGGIO SANTOS, KAREN SLIS; MONTE-ALTO-COSTA, ANDREA; DE OLIVEIRA, MARCELO G.. Combined nitric oxide-releasing poly(vinyl alcohol) film/F127 hydrogel for accelerating wound healing. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 130, p. 182-191, JUN 1 2015. (13/21936-4, 08/57560-0)

PAPADIMITRIOU, ALEXANDROS; PEIXOTO, ELISA B. M. I.; SILVA, KAMILA C.; LOPES DE FARIA, JACQUELINE M.; LOPES DE FARIA, JOSE B.. Inactivation of AMPK Mediates High Phosphate-Induced Extracellular Matrix Accumulation via NOX4/TGF beta-1 Signaling in Human Mesangial Cells. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 34, n. 4, p. 1260-1272, 2014. (12/22452-8, 08/57560-0)

BORGES, CYNTHIA M.; PAPADIMITRIOU, ALEXANDROS; DUARTE, DIEGO A.; DE FARIA, JACQUELINE M. LOPES; DE FARIA, JOSE B. LOPES. The use of green tea polyphenols for treating residual albuminuria in diabetic nephropathy: A double-blind randomised clinical trial. SCIENTIFIC REPORTS, v. 6, JUN 20 2016. (08/57560-0, 14/22687-0)

TALADRIZ-BLANCO, PATRICIA; DE OLIVEIRA, MARCELO G.. Enhanced photochemical nitric oxide release from a flutamide derivative incorporated in Pluronic F127 micelles. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, v. 293, p. 65-71, NOV 1 2014. (13/07173-8, 08/57560-0)

PEREIRA DE SOUZA, GABRIELA FREITAS; DE OLIVEIRA, MARCELO GANZAROLLI. Intratablet S-nitrosation: A New Approach for the Oral Administration of S-nitrosothiols as Nitric Oxide Donors. Journal of Pharmaceutical Sciences, v. 105, n. 1, p. 359-361, JAN 2016. (08/57560-0)

DUARTE, DIEGO A.; ROSALES, MARIANA AP. B.; PAPADIMITRIOU, ALEXANDROS; SILVA, KAMILA C.; AMANCIO, VITOR HUGO O.; MENDONCA, JACQUELINE N.; LOPES, NORBERTO P.; LOPES DE FARIA, JOSE B.; LOPES DE FARIA, JACQUELINE M.. Polyphenol-enriched cocoa protects the diabetic retina from glial reaction through the sirtuin pathway. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 26, n. 1, p. 64-74, JAN 2015. (08/57560-0, 09/51812-0, 10/11514-7)

PAPADIMITRIOU, ALEXANDROS; PEIXOTO, ELISA B. M. I.; SILVA, KAMILA C.; LOPES DE FARIA, JACQUELINE M.; LOPES DE FARIA, JOSE B.. Increase in AMPK brought about by cocoa is renoprotective in experimental diabetes mellitus by reducing NOX4/TGF beta-1 signaling. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 25, n. 7, p. 773-784, JUL 2014. (12/22452-8, 08/57560-0)

PAPADIMITRIOU, ALEXANDROS; SILVA, KAMILA C.; PEIXOTO, ELISA B. M. I.; BORGES, CYNTHIA M.; LOPES DE FARIA, JACQUELINE M.; LOPES DE FARIA, JOSE B.. Theobromine increases NAD(+)/Sirt-1 activity and protects the kidney under diabetic conditions. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 308, n. 3, p. F209-F225, FEB 1 2015. (12/22452-8, 08/57560-0)

DE SOUZA, GABRIELA F. P.; TALADRIZ-BLANCO, PATRICIA; VELLOSO, LICIO A.; DE OLIVEIRA, MARCELO G.. Nitric Oxide Released from Luminal S-Nitroso-N-Acetylcysteine Increases Gastric Mucosal Blood Flow. Molecules, v. 20, n. 3, p. 4109-4123, 2015. (13/07173-8, 08/57560-0)