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PVA-F-127 thermosensitive nanocarriers for the photochemical nitric oxide release

Grant number: 14/03266-4
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2014
Effective date (End): October 31, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Marcelo Ganzarolli de Oliveira
Grantee:Thatiane Cristine Camargo Marini
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:08/57560-0 - Effects of green tea (Camellia sinensis), cocoa and nitric oxide donor on diabetic nephropathy and retinopathy: contribution of the reduction of oxidative stress and inflammation and elevation of nitric oxide, AP.TEM
Associated scholarship(s):15/04267-7 - Synthesis of PVA-GSNO by RAFT polimerization, BE.EP.MS


Nitric oxide is an endogenous molecule involved in numerous biological processes such as vasodilatation, platelet aggregation and the immune system response. S-nitrosohiols (RSNOs) represent a class of NO donors endogenously found in mammals and are capable of releasing NO by thermal and photochemical pathways. Another NO donor already used in medical applications, which may also release NO photochemically, is Sodium Nitroprusside (NPS). Thus, the incorporation of these molecules into polymer matrices, may allow the topical release of NO by irradiation with visible light in a controlled maner. In this project, the RSNO S-nitrosoglutathione (GSNO) and SNP will be incorporated in thermosensitive nanocarriers composed of poly(vinyl alcohol) (PVA) and block copolymer PEO-PPO-PEO (F-127) for the photochemical NO release. These matrices are micro-heterogeneous systems composed of F-127 micelles with hydrophobic PPO cores, capable of storing the NO released from the donors allowing thus a kinetic control of NO release in localized applications. The formulations will be prepared from aqueous solutions of the polymers and will be characterized regarding their thermal properties (critical micelle temperature, CMT) by Differential Scanning Calorimetry (DSC), their micelle size distribution, by Dynamic Light Scattering (DLS) and their kinetics of photochemical NO release by following the decay of the regents spectrophotometrically and the release of NO by chemiluminescence. Such properties will be analysed regarding the potential medical-pharmaceutical uses of the formulations. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PICHETH, GUILHERME F.; MARINI, THATIANE C.; TALADRIZ-BLANCO, PATRICIA; SHIMAMOTO, GUSTAVO G.; DOS SANTOS, GIOVANNA J. V. P.; MENEAU, FLORIAN; DE OLIVEIRA, MARCELO G. Influence of Pluronic F127 microenvironments on the photochemical nitric oxide release from S-nitrosoglutathione. Journal of Colloid and Interface Science, v. 544, p. 217-229, MAY 15 2019. Web of Science Citations: 1.
CHANDRAWATI, RONA; OLESEN, MORTEN T. J.; MARINI, THATIANE C. C.; BISRA, GURPAL; GUEX, ANNE GERALDINE; DE OLIVEIRA, MARCELO G.; ZELIKIN, ALEXANDER N.; STEVENS, MOLLY M. Enzyme Prodrug Therapy Engineered into Electrospun Fibers with Embedded Liposomes for Controlled, Localized Synthesis of Therapeutics. ADVANCED HEALTHCARE MATERIALS, v. 6, n. 17 SEP 6 2017. Web of Science Citations: 11.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARINI, Thatiane Cristine Camargo. Thermosensitive micellar systems of PVA/PEO-PPO-PEO for photochemical nitric oxide release. 2016. Master's Dissertation.

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