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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

High frequency of immunodeficiency-like states in systemic lupus erythematosus: a cross-sectional study in 300 consecutive patients

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Autor(es):
Perazzio, Sandro F. ; Granados, Atila ; Salomao, Reinaldo ; Silva, Neusa P. ; Carneiro-Sampaio, Magda ; Andrade, Luis Eduardo C.
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: RHEUMATOLOGY; v. 55, n. 9, p. 1647-1655, SEP 2016.
Citações Web of Science: 1
Resumo

Objective. To determine the frequency of immunodeficiency-like states in SLE and related clinical features. Methods. Three hundred and fifteen SLE patients and 301 controls were evaluated for C4A and C4B gene copy number, immunoglobulin isotypes, IgG subclasses, total haemolytic complement (CH50), C2, C3 and neutrophil oxidative burst. C2 and C3 genes were sequenced in cases of low C2 or C3 levels. Those presenting abnormal CH50 with normal C2 and C3 underwent C1q-C9 determination. Patients with active SLE and abnormal results were re-tested after the flare or were excluded if no remission was attained. Fifteen patients were excluded on this basis. Persistent abnormal results characterized an immunodeficiency-like state. Results. A significantly higher percentage of SLE patients presented an immunodeficiency-like state compared with controls (28.7% vs 3.3%; P < 0.001), especially low immunoglobulin serum levels. Rigorous testing confirmed only two cases of C2 deficiency carriers among the SLE patients. There were significantly more SLE patients with less than two C4A copies compared with controls. SLE patients had higher frequency of low IgG(2), IgG(3), IgG(4) and IgM levels compared with controls. Patients with low IgG(3) or IgG(4) presented higher frequency of lupus nephropathy. Patients with low IgM had longer disease duration, older age at SLE onset and lower frequency of oral ulcers. Conclusion. An immunodeficiency-like state is present in a sizable fraction of SLE patients. Further studies are warranted to determine the impact of these immunodeficiency states and whether they are a primary condition or are secondary to confounding factors, including SLE itself. (AU)

Processo FAPESP: 09/53449-0 - Rastreamento de diversos tipos de imunodeficiência primária em pacientes com lúpus eritematoso sistêmico
Beneficiário:Luiz Eduardo Coelho Andrade
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/58238-4 - Autoimunidade na criança: investigação das bases moleculares e celulares da autoimunidade de início precoce
Beneficiário:Magda Maria Sales Carneiro-Sampaio
Linha de fomento: Auxílio à Pesquisa - Temático