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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effects of Dietary Exposure to Sulfamethazine on the Hematological Parameters and Hepatic Oxidative Stress Biomarkers in Nile Tilapia (Oreochromis niloticus)

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Autor(es):
Sampaio, Fernanda Garcia ; Carra, Maria Lidia ; Jonsson, Claudio Martin ; Goncalves, Vitoria Teodoro ; Dal'Bo, Genoefa ; Damacena Nunes, Katia Santos ; Valim, Jose Henrique ; Lima Dallago, Bruno Stefano ; do Nascimento de Queiroz, Sonia Claudia ; Reyes Reyes, Felix Guillermo
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: Bulletin of Environmental Contamination and Toxicology; v. 97, n. 4, p. 528-535, OCT 2016.
Citações Web of Science: 5
Resumo

Sulfamethazine (SMZ) is one of the most commonly used sulfonamide compounds in fish farming, and its physiological effects on fish are unknown. SMZ was administered to juvenile Nile tilapia (Oreochromis niloticus) at a dose level of 422 mg kg(-1) body weight, for a period of 11 days, via medicated feed. Fish were divided into two groups, the control group (CG) and the group fed with SMZ in feed. The administration of SMZ did not alter the erythrograms and leukograms of the Nile tilapia. The SMZ-fed group showed the same hepatic lipid peroxidation (LPO) concentration as the CG. Nonetheless, the oral administration of SMZ raised the hepatic catalase (CAT) and glutathione S-transferase (GST) activities, the increase probably being sufficient to prevent hepatic LPO production. The oral administration of SMZ affects the hepatic GST and CAT activities of Nile tilapia. (AU)

Processo FAPESP: 13/50452-5 - Veterinary drugs: development and validation of bioanalytical methods using LC-MS/MS and MALDI-TOF-MS and its applications in sanitary surveillance and the development of fish farming in Brazil
Beneficiário:Felix Guillermo Reyes Reyes
Linha de fomento: Auxílio à Pesquisa - Parceria para Inovação Tecnológica - PITE