Effects of Dietary Exposure to Sulfamethazine on the Hematological Parameters and Hepatic Oxidative Stress Biomarkers in Nile Tilapia (Oreochromis niloticus)

Author(s)

Sampaio, Fernanda Garcia ; Carra, Maria Lidia ; Jonsson, Claudio Martin ; Goncalves, Vitoria Teodoro ; Dal'Bo, Genoefa ; Damacena Nunes, Katia Santos ; Valim, Jose Henrique ; Lima Dallago, Bruno Stefano ; do Nascimento de Queiroz, Sonia Claudia ; Reyes Reyes, Felix Guillermo

• Document type: Journal article
• Source: Bulletin of Environmental Contamination and Toxicology; v. 97, n. 4, p. 528-535, OCT 2016.
• Web of Science Citations: 5

Abstract

Sulfamethazine (SMZ) is one of the most commonly used sulfonamide compounds in fish farming, and its physiological effects on fish are unknown. SMZ was administered to juvenile Nile tilapia (Oreochromis niloticus) at a dose level of 422 mg kg(-1) body weight, for a period of 11 days, via medicated feed. Fish were divided into two groups, the control group (CG) and the group fed with SMZ in feed. The administration of SMZ did not alter the erythrograms and leukograms of the Nile tilapia. The SMZ-fed group showed the same hepatic lipid peroxidation (LPO) concentration as the CG. Nonetheless, the oral administration of SMZ raised the hepatic catalase (CAT) and glutathione S-transferase (GST) activities, the increase probably being sufficient to prevent hepatic LPO production. The oral administration of SMZ affects the hepatic GST and CAT activities of Nile tilapia. (AU)

• FAPESP's process: 13/50452-5 - Veterinary drugs: development and validation of bioanalytical methods using LC-MS/MS and MALDI-TOF-MS and its applications in sanitary surveillance and the development of fish farming in Brazil
• Grantee: Felix Guillermo Reyes Reyes
• Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE