Alterations in male rats following in utero exposure to betamethasone suggests changes in reproductive programming

Autor(es):Mostrar menos -

Borges, Cibele S. ; Dias, Ana Flavia M. G. ; Rosa, Josiane Lima ; Silva, Patricia V. ; Silva, Raquel F. ; Barros, Aline L. ; Sanabria, Marciana ; Guerra, Marina T. ; Gregory, Mary ; Cyr, Daniel G. ; Kempinas, Wilma De G.

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE TOXICOLOGY; v. 63, p. 125-134, AUG 2016.
• Citações Web of Science: 6

Resumo

Antenatal betamethasone is used for accelerating fetal lung maturation for women at risk of preterm birth. Altered sperm parameters were reported in adult rats after intrauterine exposure to betamethasone. In this study, male rat offspring were assessed for reproductive development after dam exposure to betamethasone (0.1 mg/kg) or vehicle on Days 12, 13, 18 and 19 of pregnancy. The treatment resulted in reduction in the offspring body weight, delay in preputial separation, decreased seminal vesicle weight, testosterone levels and fertility, and increased testicular weight. In the testis, morphologically abnormal seminiferous tubules were observed, characterized by an irregular cell distribution with Sertoli cell that were displaced towards the tubular lumen. These cells expressed both Connexin 43 (Cx43) and Proliferative Nuclear Cell Antigen (PCNA). In conclusion, intrauterine betamethasone treatment appears to promote reproductive programming and impairment of rat sexual development and fertility due to, at least in part, unusual testicular disorders. (C) 2016 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 13/26557-1 - Efeitos da exposição in utero à betametasona sobre a qualidade espermática e fertilidade de ratos machos
• Beneficiário: Ana Flávia Mota Gonçalves Dias
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/25350-1 - Efeitos da exposição in útero à betametasona sobre aspectos reprodutivos de ratos machos, com ênfase na qualidade espermática e fertilidade: uma abordagem multigeracional
• Beneficiário: Cibele dos Santos Borges
• Modalidade de apoio: Bolsas no Brasil - Doutorado