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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The hepatitis delta genotype 8 in Northeast Brazil: The North Atlantic slave trade as the potential route for infection

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Cruz Santos, Max Diego ; Gomes-Gouvea, Michele Soares ; Costa Nunes, Jomar Diogo ; Fonseca Barros, Lena Maria ; Carrilho, Flair Jose ; Paiva Ferreira, Adalgisa de Sousa ; Rebello Pinho, Joao Renato
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: VIRUS RESEARCH; v. 224, p. 6-11, SEP 15 2016.
Citações Web of Science: 5

Hepatitis Delta virus (HDV) is not well known, even though HDV and Hepatitis B virus (HBV) co-infection leads to severe forms of acute And chronic liver diseases. HDV is endemic in the Western Amazon region. Recently, the HDV genotype 8 was found in chronic patients followed at the center for liver studies in the Northeast Brazil, Maranhao. Previous studies suggested that this genotype was introduced in Maranhao during the slave trade. The presence of HDV in that study, which was done outside the Amazon region, led us to investigate whether the virus is found infecting individuals in other regions of Maranhao as well. Thus, we screened ninety-two HBsAg positive individuals from five Municipalities of Maranhao for anti-HD antibody and eight were found positive (8.7%). These eight positive individuals were submitted to polymerase chain reaction (PCR) to investigate active HDV infection. Half of Them were positive for a fragment sequence of the delta antigen; their sequence samples were submitted to genotype characterization by phylogenetic analysis. All sequences clustered in a unique branch of the tree separated from the other branch described in Africa. Our study confirmed the presence of HDV-8 in Maranhao. These infected individuals had no evidence of contact with African people. Furthermore, we found individuals infected with HDV-8 in two more different municipalities. More studies like ours are urgent because the co-infection HBV/HDV is more difficult to treat. Identification of the endemic regions and implementation of healthy policies for preventing this infection are urgent in this region. (C) 2016 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 09/53946-3 - EMU: aquisição de analisador genético de DNA para o sequenciamento automático de DNA
Beneficiário:João Renato Rebello Pinho
Linha de fomento: Auxílio à Pesquisa - Programa Equipamentos Multiusuários