Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats

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Farah, Daniela ; Nunes, Jonas ; Sartori, Michelle ; Dias, Danielle da Silva ; Sirvente, Raquel ; Silva, Maikon B. ; Fiorino, Patricia ; Morris, Mariana ; Llesuy, Susana ; Farah, Vera ; Irigoyen, Maria-Claudia ; De Angelis, Katia

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 11, n. 12 DEC 8 2016.
• Citações Web of Science: 8

Resumo

The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group):Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42 +/- 0.04 vs. SC:0.24 +/- 0.05) and in arterial pressure (SF:122 +/- 3 vs. SC:113 +/- 1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidationSF: 3.30 +/- 0.09 vs. SC:1.45 +/- 0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)SF: 2.5 +/- 0.5 vs. SC:12.7 +/- 1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35 +/- 0.04), arterial pressure (118 +/- 2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training. (AU)

• Processo FAPESP: 12/01873-5 - Efeitos do treinamento físico aeróbio nas disfunções cardiometabólicas induzidas pela sobrecarga de frutose desde o desmame em ratos.
• Beneficiário: Daniela de Moura Azevedo Tuma Farah
• Linha de fomento: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 15/11223-6 - Curso temporal das alterações neuroimunes induzidas pelo consumo crônico de frutose em ratos normotensos e hipertensos: papel do treinamento físico aeróbio
• Beneficiário: Kátia de Angelis Lobo D Avila
• Linha de fomento: Auxílio à Pesquisa - Regular